The role of vitamin D in breast cancer
The biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, ang...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/74 |
| _version_ | 1828076004932845568 |
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| author | Tu Tu Aung Sreenivasa R. Chandana Karl J. D’Silva Nikolay V. Dimitrov |
| author_facet | Tu Tu Aung Sreenivasa R. Chandana Karl J. D’Silva Nikolay V. Dimitrov |
| author_sort | Tu Tu Aung |
| collection | DOAJ |
| description | The biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, angiogenesis, and hypoxia, all of which are related to the breast cancer growth, progression and metastasis. A large percentage of the industrial-world population is deficient in vitamin D. Epidemiological evidence suggests that vitamin D deficiency increases the risk of breast cancer. Vitamin D may have synergistic, additive, or antagonistic effects when combined with other therapeutic agents against breast cancer. Vitamin D appears to depress aromatase inhibitor by acting through cytochrome P 450. This evidence along with pre-clinical and clinical studies, justify the inclusion of vitamin D in future clinical trials related to breast cancer in order to determine its efficacy as a part of the breast cancer therapeutic armament. |
| first_indexed | 2024-04-11T02:08:13Z |
| format | Article |
| id | doaj.art-493b401fe91342c8b2064aec94b99bee |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T02:08:13Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-493b401fe91342c8b2064aec94b99bee2023-01-03T02:36:57ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652011-12-013110.4081/oncol.2009.1968The role of vitamin D in breast cancerTu Tu Aung0Sreenivasa R. Chandana1Karl J. D’Silva2Nikolay V. Dimitrov3Division of Hematology/Oncology, Department of Medicine, Michigan State University, East LansingDivision of Hematology/Oncology, Department of Medicine, Michigan State University, East LansingDivision of Hematology/Oncology, Department of Medicine, Michigan State University, East LansingDivision of Hematology/Oncology, Department of Medicine, Michigan State University, East LansingThe biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, angiogenesis, and hypoxia, all of which are related to the breast cancer growth, progression and metastasis. A large percentage of the industrial-world population is deficient in vitamin D. Epidemiological evidence suggests that vitamin D deficiency increases the risk of breast cancer. Vitamin D may have synergistic, additive, or antagonistic effects when combined with other therapeutic agents against breast cancer. Vitamin D appears to depress aromatase inhibitor by acting through cytochrome P 450. This evidence along with pre-clinical and clinical studies, justify the inclusion of vitamin D in future clinical trials related to breast cancer in order to determine its efficacy as a part of the breast cancer therapeutic armament.http://www.oncologyreviews.org/index.php/or/article/view/74Vitamin D - Breast cancer - Carcinogenesis - Prevention - Treatment |
| spellingShingle | Tu Tu Aung Sreenivasa R. Chandana Karl J. D’Silva Nikolay V. Dimitrov The role of vitamin D in breast cancer Oncology Reviews Vitamin D - Breast cancer - Carcinogenesis - Prevention - Treatment |
| title | The role of vitamin D in breast cancer |
| title_full | The role of vitamin D in breast cancer |
| title_fullStr | The role of vitamin D in breast cancer |
| title_full_unstemmed | The role of vitamin D in breast cancer |
| title_short | The role of vitamin D in breast cancer |
| title_sort | role of vitamin d in breast cancer |
| topic | Vitamin D - Breast cancer - Carcinogenesis - Prevention - Treatment |
| url | http://www.oncologyreviews.org/index.php/or/article/view/74 |
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