A microengineered Brain-Chip to model neuroinflammation in humans

A microengineered Brain-Chip to model neuroinflammation in humans

Summary: Species differences in brain and blood–brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases. Here, we present a human organotypic microphysiological system (MPS) that includes endothelial-lik...

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Bibliographic Details
Main Authors: Iosif Pediaditakis, Konstantia R. Kodella, Dimitris V. Manatakis, Christopher Y. Le, Sonalee Barthakur, Alexander Sorets, Achille Gravanis, Lorna Ewart, Lee L. Rubin, Elias S. Manolakos, Christopher D. Hinojosa, Katia Karalis
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Biomedical engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222010859

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