Behçet's disease: Clinical and demographic associations
AIM: To comparatively study the clinical manifestations, sexual and HLA-B51 associations in patients with Behçet's disease (BD) in two ethnic groups/MATERIAL AND METHODS: The authors examined 143 patients with the valid diagnosis of BD who were divided into 2 groups: 1) 85 patients, the dweller...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2013-05-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31277 |
| _version_ | 1811204563851542528 |
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| author | Z S Alekberova F I Izmailova M T Kudaev |
| author_facet | Z S Alekberova F I Izmailova M T Kudaev |
| author_sort | Z S Alekberova |
| collection | DOAJ |
| description | AIM: To comparatively study the clinical manifestations, sexual and HLA-B51 associations in patients with Behçet's disease (BD) in two ethnic groups/MATERIAL AND METHODS: The authors examined 143 patients with the valid diagnosis of BD who were divided into 2 groups: 1) 85 patients, the dwellers of Dagestan (a multiethnic cohort), 63 men and 22 women (mean age 29±7.4 years); 2) 58 Russian men and women (mean age 33±11.7 years)/RESULTS: Two major criteria for BD, such as aphthous stomatitis and external genital ulcers, were found with the same frequency. Panuveitis and angiitis of the retina were diagnosed more frequently in the Dagestani population with BD than in the Russians. Out of the minor criteria for BD, the incidence of lower limb deep venous thrombosis was 23% for the Dagestanis versus 3% for the Russians. Arterial thromboses and pulmonary artery aneurysms became causes of death in 4 in 5 men aged 19-23 years from their Dagestani ancestry. HLA B51 (B marker) was found in the dwellers of Dagestan: in 70% of the men and 40% of the women who had BD/CONCLUSION: BD runs a more severe course in male patients and is characterized by severe eye diseases and the systematic pattern of the process at young age. Gender-specific and genetic aspects call for further comparative investigations on large ethnic patient cohorts of other ancestries. |
| first_indexed | 2024-04-12T03:15:16Z |
| format | Article |
| id | doaj.art-493c22916cf342378159d3bd6f27213a |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T03:15:16Z |
| publishDate | 2013-05-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-493c22916cf342378159d3bd6f27213a2022-12-22T03:50:08Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422013-05-01855485228293Behçet's disease: Clinical and demographic associationsZ S AlekberovaF I IzmailovaM T KudaevAIM: To comparatively study the clinical manifestations, sexual and HLA-B51 associations in patients with Behçet's disease (BD) in two ethnic groups/MATERIAL AND METHODS: The authors examined 143 patients with the valid diagnosis of BD who were divided into 2 groups: 1) 85 patients, the dwellers of Dagestan (a multiethnic cohort), 63 men and 22 women (mean age 29±7.4 years); 2) 58 Russian men and women (mean age 33±11.7 years)/RESULTS: Two major criteria for BD, such as aphthous stomatitis and external genital ulcers, were found with the same frequency. Panuveitis and angiitis of the retina were diagnosed more frequently in the Dagestani population with BD than in the Russians. Out of the minor criteria for BD, the incidence of lower limb deep venous thrombosis was 23% for the Dagestanis versus 3% for the Russians. Arterial thromboses and pulmonary artery aneurysms became causes of death in 4 in 5 men aged 19-23 years from their Dagestani ancestry. HLA B51 (B marker) was found in the dwellers of Dagestan: in 70% of the men and 40% of the women who had BD/CONCLUSION: BD runs a more severe course in male patients and is characterized by severe eye diseases and the systematic pattern of the process at young age. Gender-specific and genetic aspects call for further comparative investigations on large ethnic patient cohorts of other ancestries.https://ter-arkhiv.ru/0040-3660/article/view/31277behçet's diseaseethnicitydemographic indicatorsclinical polymorphismhla-b51hla-b51 |
| spellingShingle | Z S Alekberova F I Izmailova M T Kudaev Behçet's disease: Clinical and demographic associations Терапевтический архив behçet's disease ethnicity demographic indicators clinical polymorphism hla-b51 hla-b51 |
| title | Behçet's disease: Clinical and demographic associations |
| title_full | Behçet's disease: Clinical and demographic associations |
| title_fullStr | Behçet's disease: Clinical and demographic associations |
| title_full_unstemmed | Behçet's disease: Clinical and demographic associations |
| title_short | Behçet's disease: Clinical and demographic associations |
| title_sort | behcet s disease clinical and demographic associations |
| topic | behçet's disease ethnicity demographic indicators clinical polymorphism hla-b51 hla-b51 |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31277 |
| work_keys_str_mv | AT zsalekberova behcetsdiseaseclinicalanddemographicassociations AT fiizmailova behcetsdiseaseclinicalanddemographicassociations AT mtkudaev behcetsdiseaseclinicalanddemographicassociations |