An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients
Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.884724/full |
| _version_ | 1818018766522417152 |
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| author | Florian Scheichel Florian Scheichel Daniel Pinggera Branko Popadic Branko Popadic Camillo Sherif Camillo Sherif Franz Marhold Franz Marhold Christian Franz Freyschlag |
| author_facet | Florian Scheichel Florian Scheichel Daniel Pinggera Branko Popadic Branko Popadic Camillo Sherif Camillo Sherif Franz Marhold Franz Marhold Christian Franz Freyschlag |
| author_sort | Florian Scheichel |
| collection | DOAJ |
| description | Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients. |
| first_indexed | 2024-04-14T07:44:06Z |
| format | Article |
| id | doaj.art-493efeaad0a94aa8a624fa105ce3b6db |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-14T07:44:06Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-493efeaad0a94aa8a624fa105ce3b6db2022-12-22T02:05:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.884724884724An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent PatientsFlorian Scheichel0Florian Scheichel1Daniel Pinggera2Branko Popadic3Branko Popadic4Camillo Sherif5Camillo Sherif6Franz Marhold7Franz Marhold8Christian Franz Freyschlag9Karl Landsteiner University of Health Sciences, Krems, AustriaDepartment of Neurosurgery, University Hospital St. Poelten, St. Poelten, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaKarl Landsteiner University of Health Sciences, Krems, AustriaDepartment of Neurosurgery, University Hospital St. Poelten, St. Poelten, AustriaKarl Landsteiner University of Health Sciences, Krems, AustriaDepartment of Neurosurgery, University Hospital St. Poelten, St. Poelten, AustriaKarl Landsteiner University of Health Sciences, Krems, AustriaDepartment of Neurosurgery, University Hospital St. Poelten, St. Poelten, AustriaDepartment of Neurosurgery, Medical University of Innsbruck, Innsbruck, AustriaPrimary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.884724/fullPrimary central nervous system lymphoma (PCNSL)corticosteroid therapydiagnostic workupdiagnostic delaydiagnostic yield |
| spellingShingle | Florian Scheichel Florian Scheichel Daniel Pinggera Branko Popadic Branko Popadic Camillo Sherif Camillo Sherif Franz Marhold Franz Marhold Christian Franz Freyschlag An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients Frontiers in Oncology Primary central nervous system lymphoma (PCNSL) corticosteroid therapy diagnostic workup diagnostic delay diagnostic yield |
| title | An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients |
| title_full | An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients |
| title_fullStr | An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients |
| title_full_unstemmed | An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients |
| title_short | An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients |
| title_sort | update on neurosurgical management of primary cns lymphoma in immunocompetent patients |
| topic | Primary central nervous system lymphoma (PCNSL) corticosteroid therapy diagnostic workup diagnostic delay diagnostic yield |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.884724/full |
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