Outcomes of kidneys used for transplantation: an analysis of survival and function
IntroductionKidney transplant recipients expect to survive the procedure with sufficient renal function for reliable dialysis freedom.MethodsTransplant outcomes (survival and estimated renal function) were assessed after live and deceased donor transplantation from the US national database. Outcomes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2024.1335999/full |
| _version_ | 1827160597756641280 |
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| author | Timothy L. Pruett Paola Martin Diwakar Gupta |
| author_facet | Timothy L. Pruett Paola Martin Diwakar Gupta |
| author_sort | Timothy L. Pruett |
| collection | DOAJ |
| description | IntroductionKidney transplant recipients expect to survive the procedure with sufficient renal function for reliable dialysis freedom.MethodsTransplant outcomes (survival and estimated renal function) were assessed after live and deceased donor transplantation from the US national database. Outcomes were stratified by age (donor and recipient) and donor type.ResultsAggregate recipient outcomes were better transplanting living vs deceased donated kidneys. However, when stratified by the one-year renal function (within KDIGO CKD stage stratifications), surviving recipients had clinically similar dialysis-freedom, irrespective of donor type or age. The major outcome differences for recipients of age-stratified live and deceased kidneys was 1) the increasing frequency of one-year graft failures and 2) the increasing likelihood of severely limited renal function (CKD 4/5) with advancing donor age. Over 30% of recipients of deceased kidneys >65 years had either one-year graft failure or severely limited renal function contrasted to less than 15% of recipients of live kidneys aged >65 years.ConclusionsEvolving techniques to reduce adverse events after urgent vs elective procedures, plus improved transplant outcome predictability with increased-age deceased donor kidneys using advanced predictive analytics (using age-stratified live kidney transplantation outcomes as a relevant reference point) should facilitate similar kidney transplant outcomes, irrespective of donor type. |
| first_indexed | 2024-03-07T15:44:22Z |
| format | Article |
| id | doaj.art-49406c87b59b4077afa45fac909156b9 |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2025-03-21T00:15:34Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-49406c87b59b4077afa45fac909156b92024-08-03T09:19:44ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402024-03-01310.3389/frtra.2024.13359991335999Outcomes of kidneys used for transplantation: an analysis of survival and functionTimothy L. Pruett0Paola Martin1Diwakar Gupta2Division of Transplantation, University of Minnesota School of Medicine, Minneapolis, MN, United StatesODT, Kelley School of Business, Indiana University, Bloomington, IN, United StatesIROM, The McCombs School of Business at University of Texas (Austin), Austin, TX, United StatesIntroductionKidney transplant recipients expect to survive the procedure with sufficient renal function for reliable dialysis freedom.MethodsTransplant outcomes (survival and estimated renal function) were assessed after live and deceased donor transplantation from the US national database. Outcomes were stratified by age (donor and recipient) and donor type.ResultsAggregate recipient outcomes were better transplanting living vs deceased donated kidneys. However, when stratified by the one-year renal function (within KDIGO CKD stage stratifications), surviving recipients had clinically similar dialysis-freedom, irrespective of donor type or age. The major outcome differences for recipients of age-stratified live and deceased kidneys was 1) the increasing frequency of one-year graft failures and 2) the increasing likelihood of severely limited renal function (CKD 4/5) with advancing donor age. Over 30% of recipients of deceased kidneys >65 years had either one-year graft failure or severely limited renal function contrasted to less than 15% of recipients of live kidneys aged >65 years.ConclusionsEvolving techniques to reduce adverse events after urgent vs elective procedures, plus improved transplant outcome predictability with increased-age deceased donor kidneys using advanced predictive analytics (using age-stratified live kidney transplantation outcomes as a relevant reference point) should facilitate similar kidney transplant outcomes, irrespective of donor type.https://www.frontiersin.org/articles/10.3389/frtra.2024.1335999/fullkidney transplantationoutcomeslive donationdeceased donationeGFR |
| spellingShingle | Timothy L. Pruett Paola Martin Diwakar Gupta Outcomes of kidneys used for transplantation: an analysis of survival and function Frontiers in Transplantation kidney transplantation outcomes live donation deceased donation eGFR |
| title | Outcomes of kidneys used for transplantation: an analysis of survival and function |
| title_full | Outcomes of kidneys used for transplantation: an analysis of survival and function |
| title_fullStr | Outcomes of kidneys used for transplantation: an analysis of survival and function |
| title_full_unstemmed | Outcomes of kidneys used for transplantation: an analysis of survival and function |
| title_short | Outcomes of kidneys used for transplantation: an analysis of survival and function |
| title_sort | outcomes of kidneys used for transplantation an analysis of survival and function |
| topic | kidney transplantation outcomes live donation deceased donation eGFR |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2024.1335999/full |
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