Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation?
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with various clinical manifestations, including skin lesions. In particular, during the COVID-19 pandemic lock-down period numerous chilblain-like lesions, mainly located on the f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pediatric Reports |
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| Online Access: | https://www.mdpi.com/2036-7503/13/2/25 |
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| author | Giuseppe Ingravallo Francesco Mazzotta Leonardo Resta Sara Sablone Gerardo Cazzato Antonietta Cimmino Roberta Rossi Anna Colagrande Beniamino Ferrante Teresa Troccoli Ernesto Bonifazi |
| author_facet | Giuseppe Ingravallo Francesco Mazzotta Leonardo Resta Sara Sablone Gerardo Cazzato Antonietta Cimmino Roberta Rossi Anna Colagrande Beniamino Ferrante Teresa Troccoli Ernesto Bonifazi |
| author_sort | Giuseppe Ingravallo |
| collection | DOAJ |
| description | Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with various clinical manifestations, including skin lesions. In particular, during the COVID-19 pandemic lock-down period numerous chilblain-like lesions, mainly located on the feet, were observed in adolescents. The latter were often asymptomatic or associated with very mild respiratory symptoms. Here, we report three cases of acral nodular lesions in SARS-CoV-2 swab-negative adolescents with histological findings of chronic immune-mediated inflammation and immunohistochemical evidence of SARS-CoV-2 spike glycoproteins in endothelial cells and eccrine sweat glands. In one of these cases, the virus presence was confirmed by electron microscopy. |
| first_indexed | 2024-03-10T12:28:53Z |
| format | Article |
| id | doaj.art-49419781f47444249a0c24aafea78e61 |
| institution | Directory Open Access Journal |
| issn | 2036-7503 |
| language | English |
| last_indexed | 2024-03-10T12:28:53Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-49419781f47444249a0c24aafea78e612023-11-21T14:47:39ZengMDPI AGPediatric Reports2036-75032021-04-0113218118810.3390/pediatric13020025Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation?Giuseppe Ingravallo0Francesco Mazzotta1Leonardo Resta2Sara Sablone3Gerardo Cazzato4Antonietta Cimmino5Roberta Rossi6Anna Colagrande7Beniamino Ferrante8Teresa Troccoli9Ernesto Bonifazi10Department of Emergency and Organ Transplantation, Section of Pathology, University of Bari Aldo Moro, 11, 70124 Bari, ItalyPediatric Dermatology and Surgery Outpatients Department, Azienda Sanitaria Locale Barletta-Andria-Trani, 76123 Andria, ItalyDepartment of Emergency and Organ Transplantation, Section of Pathology, University of Bari Aldo Moro, 11, 70124 Bari, ItalySection of Forensic Medicine, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Pathology, University of Bari Aldo Moro, 11, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Pathology, University of Bari Aldo Moro, 11, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Pathology, University of Bari Aldo Moro, 11, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, Section of Pathology, University of Bari Aldo Moro, 11, 70124 Bari, ItalyPediatric Dermatology and Surgery Outpatients Department, Azienda Sanitaria Locale Barletta-Andria-Trani, 76123 Andria, ItalyPediatric Dermatology and Surgery Outpatients Department, Azienda Sanitaria Locale Barletta-Andria-Trani, 76123 Andria, ItalyPediatric Dermatology, University of Bari Aldo Moro, 11, 70124 Bari, ItalyCoronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with various clinical manifestations, including skin lesions. In particular, during the COVID-19 pandemic lock-down period numerous chilblain-like lesions, mainly located on the feet, were observed in adolescents. The latter were often asymptomatic or associated with very mild respiratory symptoms. Here, we report three cases of acral nodular lesions in SARS-CoV-2 swab-negative adolescents with histological findings of chronic immune-mediated inflammation and immunohistochemical evidence of SARS-CoV-2 spike glycoproteins in endothelial cells and eccrine sweat glands. In one of these cases, the virus presence was confirmed by electron microscopy.https://www.mdpi.com/2036-7503/13/2/25SARS-CoV-2skingranuloma annularechilblains |
| spellingShingle | Giuseppe Ingravallo Francesco Mazzotta Leonardo Resta Sara Sablone Gerardo Cazzato Antonietta Cimmino Roberta Rossi Anna Colagrande Beniamino Ferrante Teresa Troccoli Ernesto Bonifazi Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation? Pediatric Reports SARS-CoV-2 skin granuloma annulare chilblains |
| title | Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation? |
| title_full | Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation? |
| title_fullStr | Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation? |
| title_full_unstemmed | Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation? |
| title_short | Inflammatory Skin Lesions in Three SARS-CoV-2 Swab-Negative Adolescents: A Possible COVID-19 Sneaky Manifestation? |
| title_sort | inflammatory skin lesions in three sars cov 2 swab negative adolescents a possible covid 19 sneaky manifestation |
| topic | SARS-CoV-2 skin granuloma annulare chilblains |
| url | https://www.mdpi.com/2036-7503/13/2/25 |
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