Mitoxantrone-Surfactant Interactions: A Physicochemical Overview
Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/10/1356 |
| _version_ | 1811195198323032064 |
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| author | Mirela Enache Ana Maria Toader Madalin Iancu Enache |
| author_facet | Mirela Enache Ana Maria Toader Madalin Iancu Enache |
| author_sort | Mirela Enache |
| collection | DOAJ |
| description | Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed. |
| first_indexed | 2024-04-12T00:39:23Z |
| format | Article |
| id | doaj.art-4941e22ec4b04af494acd0ff9057375e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T00:39:23Z |
| publishDate | 2016-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4941e22ec4b04af494acd0ff9057375e2022-12-22T03:55:03ZengMDPI AGMolecules1420-30492016-10-012110135610.3390/molecules21101356molecules21101356Mitoxantrone-Surfactant Interactions: A Physicochemical OverviewMirela Enache0Ana Maria Toader1Madalin Iancu Enache2Institute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, RomaniaInstitute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, RomaniaInstitute of Biology Bucharest, Romanian Academy, Splaiul Independentei 296, Bucharest 060031, RomaniaMitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed.http://www.mdpi.com/1420-3049/21/10/1356mitoxantronesurfactantsmicellesbinding constantpartition coefficient |
| spellingShingle | Mirela Enache Ana Maria Toader Madalin Iancu Enache Mitoxantrone-Surfactant Interactions: A Physicochemical Overview Molecules mitoxantrone surfactants micelles binding constant partition coefficient |
| title | Mitoxantrone-Surfactant Interactions: A Physicochemical Overview |
| title_full | Mitoxantrone-Surfactant Interactions: A Physicochemical Overview |
| title_fullStr | Mitoxantrone-Surfactant Interactions: A Physicochemical Overview |
| title_full_unstemmed | Mitoxantrone-Surfactant Interactions: A Physicochemical Overview |
| title_short | Mitoxantrone-Surfactant Interactions: A Physicochemical Overview |
| title_sort | mitoxantrone surfactant interactions a physicochemical overview |
| topic | mitoxantrone surfactants micelles binding constant partition coefficient |
| url | http://www.mdpi.com/1420-3049/21/10/1356 |
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