Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats
Bruguiera gymnorhiza (BG) has potential as a functional food because of its dietary fibre content and bioactive components such as flavonoids and phenolic compounds. However, it is not studied in the context of diet-related disease prevention. In the present study, we aimed to investigate the effect...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022021752 |
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| author | Rinta Amalia Adriyan Pramono Diana Nur Afifah Etika Ratna Noer Muflihatul Muniroh Andri Cahyo Kumoro |
| author_facet | Rinta Amalia Adriyan Pramono Diana Nur Afifah Etika Ratna Noer Muflihatul Muniroh Andri Cahyo Kumoro |
| author_sort | Rinta Amalia |
| collection | DOAJ |
| description | Bruguiera gymnorhiza (BG) has potential as a functional food because of its dietary fibre content and bioactive components such as flavonoids and phenolic compounds. However, it is not studied in the context of diet-related disease prevention. In the present study, we aimed to investigate the effects of Bruguiera gymnorhiza fruit flour (BGF) on satiety hormone, lipid profile, systemic inflammation, body weight, and caecum SCFA levels in diet-induced obese rats. A total of 28 obese male Wistar rats were divided into four groups. Group 1 (K1) was given a standard chow, group 2 (K2) standard chow + orlistat, group 3 (P1) standard chow + BGF 2 g/200 g BW/day, and group 4 (P2) standard chow + BGF 4 g/200 g BW/day for 28 days. The levels of GLP-1, PYY, total cholesterol (TC), triglyceride (TG), HDL, IL-6, TNF-α, and body weight were measured before and after the intervention; meanwhile, the caecum SCFA levels were assessed only after the intervention. In this study, BGF intervention increased the dose-dependent plasma GLP-1 and PYY levels (P < 0.000). In addition, BGF intervention also decreased lipid profiles (TC & TG) (P < 0.000, respectively) and systemic inflammation in a dose-dependent manner. Finally, acetate, propionate, and total SCFA concentrations were higher in the BGF intervention group (P2) compared to the other groups (p < 0.05). The SCFA levels were associated with satiety hormones, lipids, and systemic inflammation (P < 0.05). The BGF intervention improved satiety hormone, lipid profile, systemic inflammation, and SCFA levels. |
| first_indexed | 2024-04-12T15:15:09Z |
| format | Article |
| id | doaj.art-49438256a2764c6c9899439cd3e7ec66 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-12T15:15:09Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-49438256a2764c6c9899439cd3e7ec662022-12-22T03:27:38ZengElsevierHeliyon2405-84402022-10-01810e10887Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar ratsRinta Amalia0Adriyan Pramono1Diana Nur Afifah2Etika Ratna Noer3Muflihatul Muniroh4Andri Cahyo Kumoro5Department of Nutrition, Faculty of Medicine, Universitas Diponegoro, Semarang, IndonesiaDepartment of Nutrition, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Center of Nutrition Research, Universitas Diponegoro, Semarang, Indonesia; Corresponding author.Department of Nutrition, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Center of Nutrition Research, Universitas Diponegoro, Semarang, IndonesiaDepartment of Nutrition, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Center of Nutrition Research, Universitas Diponegoro, Semarang, IndonesiaDepartment of Physiology, Faculty of Medicine, Universitas Diponegoro, Semarang, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Semarang, IndonesiaBruguiera gymnorhiza (BG) has potential as a functional food because of its dietary fibre content and bioactive components such as flavonoids and phenolic compounds. However, it is not studied in the context of diet-related disease prevention. In the present study, we aimed to investigate the effects of Bruguiera gymnorhiza fruit flour (BGF) on satiety hormone, lipid profile, systemic inflammation, body weight, and caecum SCFA levels in diet-induced obese rats. A total of 28 obese male Wistar rats were divided into four groups. Group 1 (K1) was given a standard chow, group 2 (K2) standard chow + orlistat, group 3 (P1) standard chow + BGF 2 g/200 g BW/day, and group 4 (P2) standard chow + BGF 4 g/200 g BW/day for 28 days. The levels of GLP-1, PYY, total cholesterol (TC), triglyceride (TG), HDL, IL-6, TNF-α, and body weight were measured before and after the intervention; meanwhile, the caecum SCFA levels were assessed only after the intervention. In this study, BGF intervention increased the dose-dependent plasma GLP-1 and PYY levels (P < 0.000). In addition, BGF intervention also decreased lipid profiles (TC & TG) (P < 0.000, respectively) and systemic inflammation in a dose-dependent manner. Finally, acetate, propionate, and total SCFA concentrations were higher in the BGF intervention group (P2) compared to the other groups (p < 0.05). The SCFA levels were associated with satiety hormones, lipids, and systemic inflammation (P < 0.05). The BGF intervention improved satiety hormone, lipid profile, systemic inflammation, and SCFA levels.http://www.sciencedirect.com/science/article/pii/S2405844022021752Bruguiera gymnorhizaDietary fibreBioactive componentThe satiety hormoneLipid profileInflammatory |
| spellingShingle | Rinta Amalia Adriyan Pramono Diana Nur Afifah Etika Ratna Noer Muflihatul Muniroh Andri Cahyo Kumoro Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats Heliyon Bruguiera gymnorhiza Dietary fibre Bioactive component The satiety hormone Lipid profile Inflammatory |
| title | Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats |
| title_full | Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats |
| title_fullStr | Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats |
| title_full_unstemmed | Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats |
| title_short | Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats |
| title_sort | mangrove fruit bruguiera gymnorhiza increases circulating glp 1 and pyy modulates lipid profiles and reduces systemic inflammation by improving scfa levels in obese wistar rats |
| topic | Bruguiera gymnorhiza Dietary fibre Bioactive component The satiety hormone Lipid profile Inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022021752 |
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