Cardiac-Specific Overexpression of Silent Information Regulator 1 Protects Against Heart and Kidney Deterioration in Cardiorenal Syndrome via Inhibition of Endoplasmic Reticulum Stress

Cardiac-Specific Overexpression of Silent Information Regulator 1 Protects Against Heart and Kidney Deterioration in Cardiorenal Syndrome via Inhibition of Endoplasmic Reticulum Stress

Background/Aims: Increased endoplasmic reticulum (ER) stress contributes to development of cardiorenal syndrome (CRS), and Silent Information Regulator 1 (SIRT1), a class III histone deacetylase, may have protective effects on heart and renal disease, by reducing ER stress. We aimed to determine if...

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Bibliographic Details
Main Authors: Dong Huang, Mei-ling Yan, Kan-kai Chen, Rong Sun, Zhi-feng Dong, Peng-long Wu, Shuai Li, Guang-shuo Zhu, Shi-xin Ma, Ye-sheng Pan, Jing-wei Pan, Wei Zhu, Jun Xu, Meng Wei, Jing-bo Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cardiorenal syndrome
Genetically Altered and Transgenic Models
Myocardial Infarction
Nephrology and Kidney
Remodeling
Online Access:https://www.karger.com/Article/FullText/488404

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