Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains
Background: Given that reports have suggested SARS-CoV-2 can be transmitted via conjunctiva, the ability of contact lens (CL) care products to reduce the infectiousness of two seasonal human coronavirus (HCoV) (HCoV-229E and HCoV-OC43) surrogates for SARS-CoV-2 was investigated. Methods: Biotrue and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/11/4/472 |
| _version_ | 1797444291891560448 |
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| author | Christiane Lourenco Nogueira Scott Joseph Boegel Manish Shukla William Ngo Lyndon Jones Marc G. Aucoin |
| author_facet | Christiane Lourenco Nogueira Scott Joseph Boegel Manish Shukla William Ngo Lyndon Jones Marc G. Aucoin |
| author_sort | Christiane Lourenco Nogueira |
| collection | DOAJ |
| description | Background: Given that reports have suggested SARS-CoV-2 can be transmitted via conjunctiva, the ability of contact lens (CL) care products to reduce the infectiousness of two seasonal human coronavirus (HCoV) (HCoV-229E and HCoV-OC43) surrogates for SARS-CoV-2 was investigated. Methods: Biotrue and Boston Simplus (Bausch&Lomb), OPTI-FREE Puremoist and Clear Care (Alcon), and cleadew and cleadew GP (Ophtecs) were tested. Their ability to inactivate HCoV was evaluated using contact times of 4 and 6 h as well as 1% and 10% of virus inoculum. Results: Non-oxidative systems (Biotrue, Boston Simplus, and OPTI-FREE) did not exhibit a significant log<sub>10</sub> reduction compared to controls for the two viral strains for either incubation time (all <i>p</i> > 0.05) when 10% tests were performed. For the 1% test, while Boston Simplus and OPTI-FREE exhibited a significant log<sub>10</sub> reduction of both HCoV-229E (after 6 h) and HCoV-OC43 (after either 4 or 6 h incubation), those products showed less than 1 log<sub>10</sub> reduction of the two infectious viruses. Oxidative systems based on hydrogen peroxide or povidone-iodine showed a significant log<sub>10</sub> reduction compared with the controls for both HCoV-229E and HCoV-OC43 in all tested conditions (all <i>p</i> < 0.01). Clear Care led to virus inactivation to below the limit of quantification for tests performed with 1% of inoculum after 6 h incubation, while cleadew and cleadew GP led to inactivation of the two viruses to below the limit of quantification in all tested conditions. Conclusion: Oxidative CL disinfection systems showed significant virucidal activity against HCoV-229E and HCoV-OC43, while non-oxidative systems showed minimal ability to inactivate the HCoV species examined. |
| first_indexed | 2024-03-09T13:10:29Z |
| format | Article |
| id | doaj.art-49486de1d79049d4b782abb387518ad7 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T13:10:29Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-49486de1d79049d4b782abb387518ad72023-11-30T21:42:34ZengMDPI AGPathogens2076-08172022-04-0111447210.3390/pathogens11040472Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus StrainsChristiane Lourenco Nogueira0Scott Joseph Boegel1Manish Shukla2William Ngo3Lyndon Jones4Marc G. Aucoin5Department of Chemical Engineering, University of Waterloo, Waterloo, ON N2L 3G1, CanadaDepartment of Chemical Engineering, University of Waterloo, Waterloo, ON N2L 3G1, CanadaCentre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, CanadaCentre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, CanadaCentre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, CanadaDepartment of Chemical Engineering, University of Waterloo, Waterloo, ON N2L 3G1, CanadaBackground: Given that reports have suggested SARS-CoV-2 can be transmitted via conjunctiva, the ability of contact lens (CL) care products to reduce the infectiousness of two seasonal human coronavirus (HCoV) (HCoV-229E and HCoV-OC43) surrogates for SARS-CoV-2 was investigated. Methods: Biotrue and Boston Simplus (Bausch&Lomb), OPTI-FREE Puremoist and Clear Care (Alcon), and cleadew and cleadew GP (Ophtecs) were tested. Their ability to inactivate HCoV was evaluated using contact times of 4 and 6 h as well as 1% and 10% of virus inoculum. Results: Non-oxidative systems (Biotrue, Boston Simplus, and OPTI-FREE) did not exhibit a significant log<sub>10</sub> reduction compared to controls for the two viral strains for either incubation time (all <i>p</i> > 0.05) when 10% tests were performed. For the 1% test, while Boston Simplus and OPTI-FREE exhibited a significant log<sub>10</sub> reduction of both HCoV-229E (after 6 h) and HCoV-OC43 (after either 4 or 6 h incubation), those products showed less than 1 log<sub>10</sub> reduction of the two infectious viruses. Oxidative systems based on hydrogen peroxide or povidone-iodine showed a significant log<sub>10</sub> reduction compared with the controls for both HCoV-229E and HCoV-OC43 in all tested conditions (all <i>p</i> < 0.01). Clear Care led to virus inactivation to below the limit of quantification for tests performed with 1% of inoculum after 6 h incubation, while cleadew and cleadew GP led to inactivation of the two viruses to below the limit of quantification in all tested conditions. Conclusion: Oxidative CL disinfection systems showed significant virucidal activity against HCoV-229E and HCoV-OC43, while non-oxidative systems showed minimal ability to inactivate the HCoV species examined.https://www.mdpi.com/2076-0817/11/4/472contact lens solutionsvirucidal activityhuman coronavirusHCoV-229EHCoV-OC43 |
| spellingShingle | Christiane Lourenco Nogueira Scott Joseph Boegel Manish Shukla William Ngo Lyndon Jones Marc G. Aucoin Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains Pathogens contact lens solutions virucidal activity human coronavirus HCoV-229E HCoV-OC43 |
| title | Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains |
| title_full | Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains |
| title_fullStr | Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains |
| title_full_unstemmed | Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains |
| title_short | Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains |
| title_sort | antiviral activity of contemporary contact lens care solutions against two human seasonal coronavirus strains |
| topic | contact lens solutions virucidal activity human coronavirus HCoV-229E HCoV-OC43 |
| url | https://www.mdpi.com/2076-0817/11/4/472 |
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