Polyelectrolyte Coatings for Surface Modification of Medical Implants
Polyelectrolyte multi-layer (PEM) coatings are prepared by alternative deposition of single polyelectrolyte monolayers on charged surfaces using the Layer-by-Layer (LbL) dip coating procedure. These are nanometre scaled coatings which allow fulfilling of different technical or biological requirement...
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| Format: | Article |
| Language: | English |
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De Gruyter
2018-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2018-0053 |
| _version_ | 1797740440660738048 |
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| author | Krastev Rumen Rudt Alexander Xiong Xin Hartmann Hanna |
| author_facet | Krastev Rumen Rudt Alexander Xiong Xin Hartmann Hanna |
| author_sort | Krastev Rumen |
| collection | DOAJ |
| description | Polyelectrolyte multi-layer (PEM) coatings are prepared by alternative deposition of single polyelectrolyte monolayers on charged surfaces using the Layer-by-Layer (LbL) dip coating procedure. These are nanometre scaled coatings which allow fulfilling of different technical or biological requirements. The build-up process is based on selfassembly and self-organization of polycations and polyanions on different substrates including complex geometrical structures and even closed volumes, forming homogeneous layer without defects. Depending on the proper selection of the applied polyelectrolytes, coatings with different stabilities can be prepared. Some of the coatings are stable and cannot be removed from the surface. Others are degradable and can be used as systems for controlled local drug delivery. Here we summarise the results of our experience in preparation of PEM coatings with different functionalities. PEM coatings can be used as controllable delivery system for siRNA polyplexes. They can be used to control the adhesion of different cell types on the surfaces and support e.g. the endothelialisation process on cardio-vascular medical devices as e.g. stents or reduce the immunological response of the tissue after implantation. We summarise results from physical characterisation of the coatings (e.g. film thickness, roughness, electrical charge and hydrophilicity) combined with in-vitro biological studies on adhesion of HUVEC cells. |
| first_indexed | 2024-03-12T14:12:29Z |
| format | Article |
| id | doaj.art-494a2b06dc95460da5e4428478a514c8 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-03-12T14:12:29Z |
| publishDate | 2018-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-494a2b06dc95460da5e4428478a514c82023-08-21T06:42:01ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042018-09-014121722010.1515/cdbme-2018-0053cdbme-2018-0053Polyelectrolyte Coatings for Surface Modification of Medical ImplantsKrastev Rumen0Rudt Alexander1Xiong Xin2Hartmann Hanna3Reutlingen University, Reutlingen, Germany and NMI Natural and Medical sciences institute at the University of Tübingen,Tübingen, GermanyReutlingen University,Reutlingen, GermanyNMI Natural and Medical sciences institute at the University of Tübingen,Tübingen, GermanyNMI Natural and Medical sciences institute at the University of Tübingen,Tübingen, GermanyPolyelectrolyte multi-layer (PEM) coatings are prepared by alternative deposition of single polyelectrolyte monolayers on charged surfaces using the Layer-by-Layer (LbL) dip coating procedure. These are nanometre scaled coatings which allow fulfilling of different technical or biological requirements. The build-up process is based on selfassembly and self-organization of polycations and polyanions on different substrates including complex geometrical structures and even closed volumes, forming homogeneous layer without defects. Depending on the proper selection of the applied polyelectrolytes, coatings with different stabilities can be prepared. Some of the coatings are stable and cannot be removed from the surface. Others are degradable and can be used as systems for controlled local drug delivery. Here we summarise the results of our experience in preparation of PEM coatings with different functionalities. PEM coatings can be used as controllable delivery system for siRNA polyplexes. They can be used to control the adhesion of different cell types on the surfaces and support e.g. the endothelialisation process on cardio-vascular medical devices as e.g. stents or reduce the immunological response of the tissue after implantation. We summarise results from physical characterisation of the coatings (e.g. film thickness, roughness, electrical charge and hydrophilicity) combined with in-vitro biological studies on adhesion of HUVEC cells.https://doi.org/10.1515/cdbme-2018-0053cell adhesionhuvechydrophobicitypolyelectrolyte multilayerroughnessstiffness |
| spellingShingle | Krastev Rumen Rudt Alexander Xiong Xin Hartmann Hanna Polyelectrolyte Coatings for Surface Modification of Medical Implants Current Directions in Biomedical Engineering cell adhesion huvec hydrophobicity polyelectrolyte multilayer roughness stiffness |
| title | Polyelectrolyte Coatings for Surface Modification of Medical Implants |
| title_full | Polyelectrolyte Coatings for Surface Modification of Medical Implants |
| title_fullStr | Polyelectrolyte Coatings for Surface Modification of Medical Implants |
| title_full_unstemmed | Polyelectrolyte Coatings for Surface Modification of Medical Implants |
| title_short | Polyelectrolyte Coatings for Surface Modification of Medical Implants |
| title_sort | polyelectrolyte coatings for surface modification of medical implants |
| topic | cell adhesion huvec hydrophobicity polyelectrolyte multilayer roughness stiffness |
| url | https://doi.org/10.1515/cdbme-2018-0053 |
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