The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population
Abstract Background Klotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have adverse impact on DNA methylation associated with aging. The aim of the current study was to determine the relationship between serum klotho and...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-02924-9 |
| _version_ | 1818320116984578048 |
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| author | Yuan-Yuei Chen Wei-Liang Chen |
| author_facet | Yuan-Yuei Chen Wei-Liang Chen |
| author_sort | Yuan-Yuei Chen |
| collection | DOAJ |
| description | Abstract Background Klotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have adverse impact on DNA methylation associated with aging. The aim of the current study was to determine the relationship between serum klotho and PAHs exposure in an adult population. Methods A total of 2597 participants obtained from NHANES 2015–2016 were included in this cross-sectional study. Serum klotho levels were analyzed by enzyme-linked immunosorbent assay (ELISA). PAHs exposure was estimated by urinary sample using liquid chromatography-tandem mass spectrometry. The relationship between serum klotho and exposure to PAHS was analyzed by a multivariable linear regression model. Results 2-napthol and 3-fluorene were significantly associated with decreased klotho. After fully adjusting pertinent variables, PAH exposure was significantly associated with decreased klotho, particularly in men. Conclusion In the present study we highlighted the significant association between PAHs exposure and serum klotho levels. The importance of environmental effect on aging process and age-related disorders should be paid more attention and clinical intervention is necessary. |
| first_indexed | 2024-12-13T10:19:54Z |
| format | Article |
| id | doaj.art-494ab1a25ec04e078381115c038f7b74 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-13T10:19:54Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-494ab1a25ec04e078381115c038f7b742022-12-21T23:51:12ZengBMCBMC Geriatrics1471-23182022-03-012211710.1186/s12877-022-02924-9The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult populationYuan-Yuei Chen0Wei-Liang Chen1Department of Pathology, Tri-Service General Hospital, and School of Medicine, National Defense Medical CenterDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical CenterAbstract Background Klotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have adverse impact on DNA methylation associated with aging. The aim of the current study was to determine the relationship between serum klotho and PAHs exposure in an adult population. Methods A total of 2597 participants obtained from NHANES 2015–2016 were included in this cross-sectional study. Serum klotho levels were analyzed by enzyme-linked immunosorbent assay (ELISA). PAHs exposure was estimated by urinary sample using liquid chromatography-tandem mass spectrometry. The relationship between serum klotho and exposure to PAHS was analyzed by a multivariable linear regression model. Results 2-napthol and 3-fluorene were significantly associated with decreased klotho. After fully adjusting pertinent variables, PAH exposure was significantly associated with decreased klotho, particularly in men. Conclusion In the present study we highlighted the significant association between PAHs exposure and serum klotho levels. The importance of environmental effect on aging process and age-related disorders should be paid more attention and clinical intervention is necessary.https://doi.org/10.1186/s12877-022-02924-9Polycyclic Aromatic HydrocarbonsKlothoAdult |
| spellingShingle | Yuan-Yuei Chen Wei-Liang Chen The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population BMC Geriatrics Polycyclic Aromatic Hydrocarbons Klotho Adult |
| title | The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population |
| title_full | The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population |
| title_fullStr | The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population |
| title_full_unstemmed | The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population |
| title_short | The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population |
| title_sort | relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population |
| topic | Polycyclic Aromatic Hydrocarbons Klotho Adult |
| url | https://doi.org/10.1186/s12877-022-02924-9 |
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