HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report
Abstract Background Cases of subacute thyroiditis (SAT) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination have been reported. A human leukocyte antigen (HLA) allele, HLA-B*35, appears to be involved in the pathogenesis of SAT. Case presentation We conducted HLA typing of...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01287-5 |
| _version_ | 1797864488275279872 |
|---|---|
| author | Shigemitsu Yasuda Seiya Suzuki Shinnosuke Yanagisawa Hideo Morita Akifumi Haisa Atsushi Satomura Ritsuko Nakajima Yoichi Oikawa Ikuo Inoue Akira Shimada |
| author_facet | Shigemitsu Yasuda Seiya Suzuki Shinnosuke Yanagisawa Hideo Morita Akifumi Haisa Atsushi Satomura Ritsuko Nakajima Yoichi Oikawa Ikuo Inoue Akira Shimada |
| author_sort | Shigemitsu Yasuda |
| collection | DOAJ |
| description | Abstract Background Cases of subacute thyroiditis (SAT) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination have been reported. A human leukocyte antigen (HLA) allele, HLA-B*35, appears to be involved in the pathogenesis of SAT. Case presentation We conducted HLA typing of one patient with SAT and another with both SAT and Graves’ disease (GD), which developed after SARS-CoV-2 vaccination. Patient 1, a 58-year-old Japanese man, was inoculated with a SARS-CoV-2 vaccine (BNT162b2; Pfizer, New York, NY, USA). He developed fever (38 °C), cervical pain, palpitations, and fatigue on day 10 after vaccination. Blood chemistry tests revealed thyrotoxicosis and elevated serum C-reactive protein (CRP) and slightly increased serum antithyroid-stimulating antibody (TSAb) levels. Thyroid ultrasonography revealed the characteristic findings of SAT. Patient 2, a 36-year-old Japanese woman, was inoculated twice with a SARS-CoV-2 vaccine (mRNA-1273; Moderna, Cambridge, MA, USA). She developed fever (37.8 °C) and thyroid gland pain on day 3 after the second vaccination. Blood chemistry tests revealed thyrotoxicosis and elevated serum CRP, TSAb, and antithyroid-stimulating hormone receptor antibody levels. Fever and thyroid gland pain persisted. Thyroid ultrasonography revealed the characteristic findings of SAT (i.e., slight swelling and a focal hypoechoic area with decreased blood flow). Prednisolone treatment was effective for SAT. However, thyrotoxicosis causing palpitations relapsed thereafter, for which thyroid scintigraphy with 99mtechnetium pertechnetate was conducted, and the patient was diagnosed with GD. Thiamazole treatment was then initiated, which led to improvement in symptoms. Conclusion HLA typing revealed that both patients had the HLA-B*35:01, -C*04:01, and -DPB1*05:01 alleles. Only patient 2 had the HLA-DRB1*11:01 and HLA-DQB1*03:01 alleles. The HLA-B*35:01 and HLA-C*04:01 alleles appeared to be involved in the pathogenesis of SAT after SARS-CoV-2 vaccination, and the HLA-DRB1*11:01 and HLA-DQB1*03:01 alleles were speculated to be involved in the postvaccination pathogenesis of GD. |
| first_indexed | 2024-04-09T22:52:43Z |
| format | Article |
| id | doaj.art-494be33d2ed644d4ae0f35baad13fcc5 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-09T22:52:43Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-494be33d2ed644d4ae0f35baad13fcc52023-03-22T11:33:42ZengBMCBMC Endocrine Disorders1472-68232023-03-012311910.1186/s12902-023-01287-5HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case reportShigemitsu Yasuda0Seiya Suzuki1Shinnosuke Yanagisawa2Hideo Morita3Akifumi Haisa4Atsushi Satomura5Ritsuko Nakajima6Yoichi Oikawa7Ikuo Inoue8Akira Shimada9Department of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityDepartment of Endocrinology and Diabetes, Saitama Medical UniversityAbstract Background Cases of subacute thyroiditis (SAT) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination have been reported. A human leukocyte antigen (HLA) allele, HLA-B*35, appears to be involved in the pathogenesis of SAT. Case presentation We conducted HLA typing of one patient with SAT and another with both SAT and Graves’ disease (GD), which developed after SARS-CoV-2 vaccination. Patient 1, a 58-year-old Japanese man, was inoculated with a SARS-CoV-2 vaccine (BNT162b2; Pfizer, New York, NY, USA). He developed fever (38 °C), cervical pain, palpitations, and fatigue on day 10 after vaccination. Blood chemistry tests revealed thyrotoxicosis and elevated serum C-reactive protein (CRP) and slightly increased serum antithyroid-stimulating antibody (TSAb) levels. Thyroid ultrasonography revealed the characteristic findings of SAT. Patient 2, a 36-year-old Japanese woman, was inoculated twice with a SARS-CoV-2 vaccine (mRNA-1273; Moderna, Cambridge, MA, USA). She developed fever (37.8 °C) and thyroid gland pain on day 3 after the second vaccination. Blood chemistry tests revealed thyrotoxicosis and elevated serum CRP, TSAb, and antithyroid-stimulating hormone receptor antibody levels. Fever and thyroid gland pain persisted. Thyroid ultrasonography revealed the characteristic findings of SAT (i.e., slight swelling and a focal hypoechoic area with decreased blood flow). Prednisolone treatment was effective for SAT. However, thyrotoxicosis causing palpitations relapsed thereafter, for which thyroid scintigraphy with 99mtechnetium pertechnetate was conducted, and the patient was diagnosed with GD. Thiamazole treatment was then initiated, which led to improvement in symptoms. Conclusion HLA typing revealed that both patients had the HLA-B*35:01, -C*04:01, and -DPB1*05:01 alleles. Only patient 2 had the HLA-DRB1*11:01 and HLA-DQB1*03:01 alleles. The HLA-B*35:01 and HLA-C*04:01 alleles appeared to be involved in the pathogenesis of SAT after SARS-CoV-2 vaccination, and the HLA-DRB1*11:01 and HLA-DQB1*03:01 alleles were speculated to be involved in the postvaccination pathogenesis of GD.https://doi.org/10.1186/s12902-023-01287-5Subacute thyroiditisCOVID-19SARS-CoV-2 vaccinationHLAGraves’ diseaseCase report |
| spellingShingle | Shigemitsu Yasuda Seiya Suzuki Shinnosuke Yanagisawa Hideo Morita Akifumi Haisa Atsushi Satomura Ritsuko Nakajima Yoichi Oikawa Ikuo Inoue Akira Shimada HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report BMC Endocrine Disorders Subacute thyroiditis COVID-19 SARS-CoV-2 vaccination HLA Graves’ disease Case report |
| title | HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report |
| title_full | HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report |
| title_fullStr | HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report |
| title_full_unstemmed | HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report |
| title_short | HLA typing of patients who developed subacute thyroiditis and Graves’ disease after SARS-CoV-2 vaccination: a case report |
| title_sort | hla typing of patients who developed subacute thyroiditis and graves disease after sars cov 2 vaccination a case report |
| topic | Subacute thyroiditis COVID-19 SARS-CoV-2 vaccination HLA Graves’ disease Case report |
| url | https://doi.org/10.1186/s12902-023-01287-5 |
| work_keys_str_mv | AT shigemitsuyasuda hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT seiyasuzuki hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT shinnosukeyanagisawa hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT hideomorita hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT akifumihaisa hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT atsushisatomura hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT ritsukonakajima hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT yoichioikawa hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT ikuoinoue hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport AT akirashimada hlatypingofpatientswhodevelopedsubacutethyroiditisandgravesdiseaseaftersarscov2vaccinationacasereport |