Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome
Background: Women with polycystic ovarian syndrome (PCOS) have insulin resistance and hyperinsulinemia that may play a key role in the pathogenesis of PCOS. Objectives: To determine and compare glucose-insulin ratio in hyper-insulinemic women with the polycystic ovarian syndrome and healthy contr...
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| Format: | Article |
| Language: | English |
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Shalamar Medical & Dental College, Lahore, Pakistan
2022-06-01
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| Series: | Journal of Shalamar Medical & Dental College |
| Subjects: | |
| Online Access: | https://journal.smdc.edu.pk/index.php/journal/article/view/98 |
| _version_ | 1827352301763821568 |
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| author | Roohi Jabbar Maria Hameed Saima Tabassum Saboohi Saeed Tabinda Kazmi Shazia Rashid |
| author_facet | Roohi Jabbar Maria Hameed Saima Tabassum Saboohi Saeed Tabinda Kazmi Shazia Rashid |
| author_sort | Roohi Jabbar |
| collection | DOAJ |
| description |
Background: Women with polycystic ovarian syndrome (PCOS) have insulin resistance and hyperinsulinemia that may play a key role in the pathogenesis of PCOS.
Objectives: To determine and compare glucose-insulin ratio in hyper-insulinemic women with the polycystic ovarian syndrome and healthy controls.
Materials & Methods: A cross-sectional comparative study was conducted at Lahore General Hospital. A total of 80 women 24-35 years of age were recruited from Lahore General Hospital. 50 women had PCOS, and 30 were healthy controls. PCOS was diagnosed by using the Rotterdam criteria. Height, weight, and waist circumference were measured. Glucose and insulin were estimated by the glucose oxidase method and ELISA, respectively. HOMA-IR was calculated to determine insulin resistance (IR). HOMA- β was calculated to assess the β-cell function. Fasting glucose and insulin ratio were also calculated.
Results: Mean age of the women with PCOS and healthy controls was 29.89±3.54 and 28.60±1.12 years, respectively (p>0.54). BMI and waist circumference of women with PCOS were higher compared to healthy controls (p>0.45). Fasting glucose, fasting insulin, HOMA- β, and IR were significantly higher in women with PCOS compared to healthy controls (p<0.001).
Conclusion: In addition to HOMA IR, the glucose-insulin ratio may be considered to assess hyperinsulinemia in women with polycystic ovary syndrome.
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| first_indexed | 2024-03-08T02:59:58Z |
| format | Article |
| id | doaj.art-494be8467aab41c38e7eaeeb114579e3 |
| institution | Directory Open Access Journal |
| issn | 2789-3669 2789-3677 |
| language | English |
| last_indexed | 2024-03-08T02:59:58Z |
| publishDate | 2022-06-01 |
| publisher | Shalamar Medical & Dental College, Lahore, Pakistan |
| record_format | Article |
| series | Journal of Shalamar Medical & Dental College |
| spelling | doaj.art-494be8467aab41c38e7eaeeb114579e32024-02-13T11:05:37ZengShalamar Medical & Dental College, Lahore, PakistanJournal of Shalamar Medical & Dental College2789-36692789-36772022-06-013110.53685/jshmdc.v3i1.98Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian SyndromeRoohi Jabbar0Maria Hameed1Saima Tabassum2Saboohi Saeed3Tabinda Kazmi4Shazia Rashid5Department of Biochemistry, Allama Iqbal Medical College, Lahore, PakistanDepartment of Biochemistry, Ameer u din Medical College, Lahore, PakistanDepartment of Physiology, Naizi Medical and Dental College, Sargodha, Pakistan Department of Physiology, Azra Naheed Medical College, Lahore, PakistanDepartment of Physiology, Naizi Medical and Dental College, Sargodha, PakistanDepartment IMBB, University of Lahore, Lahore, Pakistan Background: Women with polycystic ovarian syndrome (PCOS) have insulin resistance and hyperinsulinemia that may play a key role in the pathogenesis of PCOS. Objectives: To determine and compare glucose-insulin ratio in hyper-insulinemic women with the polycystic ovarian syndrome and healthy controls. Materials & Methods: A cross-sectional comparative study was conducted at Lahore General Hospital. A total of 80 women 24-35 years of age were recruited from Lahore General Hospital. 50 women had PCOS, and 30 were healthy controls. PCOS was diagnosed by using the Rotterdam criteria. Height, weight, and waist circumference were measured. Glucose and insulin were estimated by the glucose oxidase method and ELISA, respectively. HOMA-IR was calculated to determine insulin resistance (IR). HOMA- β was calculated to assess the β-cell function. Fasting glucose and insulin ratio were also calculated. Results: Mean age of the women with PCOS and healthy controls was 29.89±3.54 and 28.60±1.12 years, respectively (p>0.54). BMI and waist circumference of women with PCOS were higher compared to healthy controls (p>0.45). Fasting glucose, fasting insulin, HOMA- β, and IR were significantly higher in women with PCOS compared to healthy controls (p<0.001). Conclusion: In addition to HOMA IR, the glucose-insulin ratio may be considered to assess hyperinsulinemia in women with polycystic ovary syndrome. https://journal.smdc.edu.pk/index.php/journal/article/view/98Hyperinsulinemiaglucose insulin ratioPCOS women |
| spellingShingle | Roohi Jabbar Maria Hameed Saima Tabassum Saboohi Saeed Tabinda Kazmi Shazia Rashid Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome Journal of Shalamar Medical & Dental College Hyperinsulinemia glucose insulin ratio PCOS women |
| title | Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome |
| title_full | Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome |
| title_fullStr | Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome |
| title_full_unstemmed | Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome |
| title_short | Glucose Insulin Ratio in Hyper Insulinemic Women with Polycystic Ovarian Syndrome |
| title_sort | glucose insulin ratio in hyper insulinemic women with polycystic ovarian syndrome |
| topic | Hyperinsulinemia glucose insulin ratio PCOS women |
| url | https://journal.smdc.edu.pk/index.php/journal/article/view/98 |
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