Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response
Bovine cysticercosis is a zoonosis that affects humans in their adult form (taeniasis) and its larval is found inserted in the musculature of infected cattle (cysticerci). It is still not entirely clear how animal immune response against infection occurs, being the comprehension of this process nece...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Estadual de Londrina
2015-04-01
|
| Series: | Semina: Ciências Agrárias |
| Subjects: | |
| Online Access: | http://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/16069 |
| _version_ | 1819085481344761856 |
|---|---|
| author | Rafaella Paola Meneguete dos Guimarães-Peixoto Paulo Sérgio de Arruda Pinto Laércio dos Anjos Benjamin Leandro Licursi de Oliveira Lucas Marcon Tatiane de Oliveira Santos Letícia Ferreira da Silva Emílio Campos Acevedo-Nieto |
| author_facet | Rafaella Paola Meneguete dos Guimarães-Peixoto Paulo Sérgio de Arruda Pinto Laércio dos Anjos Benjamin Leandro Licursi de Oliveira Lucas Marcon Tatiane de Oliveira Santos Letícia Ferreira da Silva Emílio Campos Acevedo-Nieto |
| author_sort | Rafaella Paola Meneguete dos Guimarães-Peixoto |
| collection | DOAJ |
| description | Bovine cysticercosis is a zoonosis that affects humans in their adult form (taeniasis) and its larval is found inserted in the musculature of infected cattle (cysticerci). It is still not entirely clear how animal immune response against infection occurs, being the comprehension of this process necessary for the enhancement of diagnostic capacity and disease prevention. This work aimed to evaluate the evolution of the immune response in experimentally infected cattle, compared with findings in cell response by optical microscopy. Nine animals were infected at a rate of 120,000 eggs of Taenia saginata. Five of the animals were similar in the kinetics of antibody production against cysticerci, with maximal levels of IgG and IgM. The other four animals showed an immune response different from the majority, with two of them showing delayed response to infection by cysticerci while the others apparently did not have initial contact with antigens secreted by cysticerci. Regarding the cellular response, it was found that, in lesions of viable cysticerci, inflammatory cells predominated, whereas in nonviable cysticerci there were tissue repair cells in the most part, being possible to notice that the amount of migratory calcareous corpuscles are related to the death stage of the parasite. These findings are important for the understanding immune response of cattle infected with cysticercosis. |
| first_indexed | 2024-12-21T21:05:02Z |
| format | Article |
| id | doaj.art-494c7e66e41d4bf99889a43bb0a97867 |
| institution | Directory Open Access Journal |
| issn | 1676-546X 1679-0359 |
| language | English |
| last_indexed | 2024-12-21T21:05:02Z |
| publishDate | 2015-04-01 |
| publisher | Universidade Estadual de Londrina |
| record_format | Article |
| series | Semina: Ciências Agrárias |
| spelling | doaj.art-494c7e66e41d4bf99889a43bb0a978672022-12-21T18:50:18ZengUniversidade Estadual de LondrinaSemina: Ciências Agrárias1676-546X1679-03592015-04-0136278779610.5433/1679-0359.2015v36n2p787Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory responseRafaella Paola Meneguete dos Guimarães-Peixoto0 Paulo Sérgio de Arruda Pinto 1Laércio dos Anjos Benjamin2Leandro Licursi de Oliveira 3Lucas Marcon4Tatiane de Oliveira Santos5Letícia Ferreira da Silva 6Emílio Campos Acevedo-Nieto 7Universidade Federal de ViçosaUniversidade Federal de ViçosaUniversidade Federal de ViçosaUniversidade Federal de ViçosaUniversidade Federal de ViçosaUniversidade Federal de ViçosaUniversidade Federal de ViçosaUniversidade Federal de ViçosaBovine cysticercosis is a zoonosis that affects humans in their adult form (taeniasis) and its larval is found inserted in the musculature of infected cattle (cysticerci). It is still not entirely clear how animal immune response against infection occurs, being the comprehension of this process necessary for the enhancement of diagnostic capacity and disease prevention. This work aimed to evaluate the evolution of the immune response in experimentally infected cattle, compared with findings in cell response by optical microscopy. Nine animals were infected at a rate of 120,000 eggs of Taenia saginata. Five of the animals were similar in the kinetics of antibody production against cysticerci, with maximal levels of IgG and IgM. The other four animals showed an immune response different from the majority, with two of them showing delayed response to infection by cysticerci while the others apparently did not have initial contact with antigens secreted by cysticerci. Regarding the cellular response, it was found that, in lesions of viable cysticerci, inflammatory cells predominated, whereas in nonviable cysticerci there were tissue repair cells in the most part, being possible to notice that the amount of migratory calcareous corpuscles are related to the death stage of the parasite. These findings are important for the understanding immune response of cattle infected with cysticercosis.http://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/16069Morphology of cysticercosis; Kinetics of antibodies; Bovine cysticercosis; Taenia saginata |
| spellingShingle | Rafaella Paola Meneguete dos Guimarães-Peixoto Paulo Sérgio de Arruda Pinto Laércio dos Anjos Benjamin Leandro Licursi de Oliveira Lucas Marcon Tatiane de Oliveira Santos Letícia Ferreira da Silva Emílio Campos Acevedo-Nieto Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response Semina: Ciências Agrárias Morphology of cysticercosis; Kinetics of antibodies; Bovine cysticercosis; Taenia saginata |
| title | Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response |
| title_full | Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response |
| title_fullStr | Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response |
| title_full_unstemmed | Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response |
| title_short | Experimental infection in cattle: kinetics of production of IgM and IgG against bovine cysticercosis and inflammatory response |
| title_sort | experimental infection in cattle kinetics of production of igm and igg against bovine cysticercosis and inflammatory response |
| topic | Morphology of cysticercosis; Kinetics of antibodies; Bovine cysticercosis; Taenia saginata |
| url | http://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/16069 |
| work_keys_str_mv | AT rafaellapaolameneguetedosguimaraespeixoto experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT paulosergiodearrudapinto experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT laerciodosanjosbenjamin experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT leandrolicursideoliveira experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT lucasmarcon experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT tatianedeoliveirasantos experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT leticiaferreiradasilva experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse AT emiliocamposacevedonieto experimentalinfectionincattlekineticsofproductionofigmandiggagainstbovinecysticercosisandinflammatoryresponse |