Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues
New analogues of pulmonarin B were synthesized from (3,5-dibromo-4-hydroxyphenyl)acetic acid derivatives, and their antibacterial and antibiofilm activities against E. coli, S. aureus, and P. aeruginosa were evaluated. The antibacterial activity of synthesized ammonium salts against the met...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Growing Science
2024-01-01
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| Series: | Current Chemistry Letters |
| Online Access: | http://www.growingscience.com/ccl/Vol13/ccl_2023_75.pdf |
| _version_ | 1797376629213757440 |
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| author | Liubov Muzychka Iryna Boiko Nina Vrynchanu Oleg Smolii |
| author_facet | Liubov Muzychka Iryna Boiko Nina Vrynchanu Oleg Smolii |
| author_sort | Liubov Muzychka |
| collection | DOAJ |
| description | New analogues of pulmonarin B were synthesized from (3,5-dibromo-4-hydroxyphenyl)acetic acid derivatives, and their antibacterial and antibiofilm activities against E. coli, S. aureus, and P. aeruginosa were evaluated. The antibacterial activity of synthesized ammonium salts against the methicillin-resistant strain of S. aureus 222 depends on the length of the alkyl chain. Bis-quaternary ammonium salt 5 demonstrated better activity against S. aureus 222, E. coli 311, and P. aeruginosa 449 compared to mono-alkylated derivatives. Analogues of pulmonarin B 5 and 4d reduced S. aureus 222 biofilm formation by 74.5% and 89.4%, respectively. In addition, compound 4c turned out to be the most active against the biofilm formation of P. aeruginosa 449 (biomass decreased by 39.8%). |
| first_indexed | 2024-03-08T19:41:24Z |
| format | Article |
| id | doaj.art-494d94c3f28c4872baf67a205681f762 |
| institution | Directory Open Access Journal |
| issn | 1927-7296 1927-730X |
| language | English |
| last_indexed | 2024-03-08T19:41:24Z |
| publishDate | 2024-01-01 |
| publisher | Growing Science |
| record_format | Article |
| series | Current Chemistry Letters |
| spelling | doaj.art-494d94c3f28c4872baf67a205681f7622023-12-25T05:27:26ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2024-01-0113233534210.5267/j.ccl.2023.11.005Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analoguesLiubov MuzychkaIryna BoikoNina VrynchanuOleg Smolii New analogues of pulmonarin B were synthesized from (3,5-dibromo-4-hydroxyphenyl)acetic acid derivatives, and their antibacterial and antibiofilm activities against E. coli, S. aureus, and P. aeruginosa were evaluated. The antibacterial activity of synthesized ammonium salts against the methicillin-resistant strain of S. aureus 222 depends on the length of the alkyl chain. Bis-quaternary ammonium salt 5 demonstrated better activity against S. aureus 222, E. coli 311, and P. aeruginosa 449 compared to mono-alkylated derivatives. Analogues of pulmonarin B 5 and 4d reduced S. aureus 222 biofilm formation by 74.5% and 89.4%, respectively. In addition, compound 4c turned out to be the most active against the biofilm formation of P. aeruginosa 449 (biomass decreased by 39.8%).http://www.growingscience.com/ccl/Vol13/ccl_2023_75.pdf |
| spellingShingle | Liubov Muzychka Iryna Boiko Nina Vrynchanu Oleg Smolii Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues Current Chemistry Letters |
| title | Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues |
| title_full | Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues |
| title_fullStr | Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues |
| title_full_unstemmed | Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues |
| title_short | Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues |
| title_sort | synthesis antibacterial and antibiofilm activities of pulmonarin b analogues |
| url | http://www.growingscience.com/ccl/Vol13/ccl_2023_75.pdf |
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