| Summary: | <pre><strong><span>Background.</span></strong><span> Uric acid is traditionally considered as the final </span></pre><pre><span>product of human and primate DNA/RNA degradation, devoid of</span></pre><pre><span>useful physiological activity. </span><span lang="EN">However, there is an opinion that</span><span lang="EN-US"> the</span></pre><pre><span lang="EN-US">uric acid molecule, by analogy with methylxanthines (caffeine, the</span></pre><pre><span lang="EN-US">ophylin, theobromine) has physiological activity. The acquired </span></pre><pre><span lang="EN-US">experience allows us to offer a topic for future research: </span></pre><pre><span lang="EN-US">“Neurotropic and immunotropic activity of endogenous uric </span></pre><pre><span lang="EN-US">acid”. Working hypothesis. Uric acid, interacting with A<sub>1</sub> and </span></pre><pre><span lang="EN-US">A<sub>2</sub></span></pre><sub>a</sub><pre> adenosine receptors as well as phosphodiesterase and </pre><pre>Na,K-ATPase of neurons, modulates the activity of nerve </pre><pre>centers, which in turn modulate immunocytes. Perhaps the </pre><pre>direct effect of uric acid on immunocytes, since the existence of</pre><pre>theophylline-resistant and theophylline-sensitive subpopulations</pre><pre> of T-lymphocytes has long been known.<span lang="EN"> The proposed article is </span></pre><pre><span lang="EN">the first swallow of the announced project.</span></pre><pre><strong></strong><strong><span lang="EN-US">Material and Methods. </span></strong>Experiment was performed on 58 </pre><pre>healthy female Wistar rats 220-300 g. <span lang="EN-US">Among them 10 animals</span> </pre><pre>remained intact, using tap water from drinking ad libitum. <span lang="EN-US">The </span></pre><pre><span lang="EN-US">r</span>ats of <span lang="EN-US">others</span> group<span lang="EN-US">s</span> for 6 days administered through the <span lang="EN-US">tu</span>be </pre><pre><span lang="EN-US">various fluids </span>at a dose of 1<span lang="EN-US">,</span>5 m<span lang="EN-US">L</span>/100 g of body <span lang="EN-US">mass</span>.The day </pre><pre>after the completion of the drinking course <span lang="EN-US">the plasma and urine </span></pre><pre><span lang="EN-US">levels of the uric acid (uricase method) were determined</span><span class="longtext"><span lang="EN">. </span></span></pre><pre><span class="longtext"><span lang="EN"><strong>Results</strong>.</span></span><span lang="EN"> We obtained a wide range of uric acid metabolism </span></pre><pre><span lang="EN">parameters, divided into four clusters, quantitatively and </span></pre><pre><span lang="EN">qualitatively different from each other. On the basis of the </span></pre><pre><span lang="EN">accepted criteria, 29</span><span lang="EN-US">,</span><span lang="EN">3% of animals state normouricemia in </span></pre><pre><span lang="EN">combination with normal or slightly increased excretion of uric </span></pre><pre><span lang="EN">acid. In 24,1% of rats, hypouricemia is combined with normal or </span></pre><pre><span lang="EN">slightly reduced uricosuria. In 31,0% of animals normal or </span></pre><pre><span lang="EN">slightly elevated levels of plasma uric acid are accompanied by a </span></pre><pre><span lang="EN">very marked dispersion of uricosuria. The remaining 15,5% of </span></pre><pre><span lang="EN">rats expressed hyperuricemia combined with normal or slightly </span></pre><pre><span lang="EN">increased uricosuria. In the following articles, functional </span></pre><pre><span lang="EN">relationships of uricemia and uricosuria with the parameters of </span></pre><pre><span lang="EN">autonomic regulation, immunity and metabolism will be analyzed.</span></pre>
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