Radiotherapy-Related Gene Signature in Prostate Cancer
Radiotherapy for localized prostate cancer has increased the cure and survival rates of patients. Besides its local tumoricidal effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation, a phenomenon called the abscopal effect. In this study, we performed gene e...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/20/5032 |
| _version_ | 1797474500036526080 |
|---|---|
| author | Paraskevi Kogionou Sotirios P. Fortis Maria Goulielmaki Nicolas Aubert Panagiota Batsaki Sotirios Ouzounis Dionisis Cavouras Gilles Marodon Savvas Stokidis Angelos D. Gritzapis Constantin N. Baxevanis |
| author_facet | Paraskevi Kogionou Sotirios P. Fortis Maria Goulielmaki Nicolas Aubert Panagiota Batsaki Sotirios Ouzounis Dionisis Cavouras Gilles Marodon Savvas Stokidis Angelos D. Gritzapis Constantin N. Baxevanis |
| author_sort | Paraskevi Kogionou |
| collection | DOAJ |
| description | Radiotherapy for localized prostate cancer has increased the cure and survival rates of patients. Besides its local tumoricidal effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation, a phenomenon called the abscopal effect. In this study, we performed gene expression analysis on peripheral blood from prostate cancer patients obtained post- radiotherapy and showed that 6 genes, including <i>CCR7</i>, <i>FCGR2B</i>, <i>BTLA</i>, <i>CD6</i>, <i>CD3D</i>, and <i>CD3E</i>, were down-regulated by a range of 1.5–2.5-fold as compared to pre-radiotherapy samples. The expression of the signature consisting of these six genes was also significantly lower post- vs. pre-radiotherapy. These genes are involved in various tumor-promoting immune pathways and their down-regulation post-radiotherapy could be considered beneficial for patients. This is supported by the fact that low mRNA expression levels for the 6-gene signature in the prostate tumor tissue was linked to better survival. Importantly, we report that this 6-gene signature strongly correlated with a favorable prognosis regardless of poor standard clinicopathological parameters (i.e., Gleason score ≥ 8 and T3 (including T3a and T3b). Our pioneering data open the possibility that the 6-gene signature identified herein may have a predictive value, but this requires further long-term studies. |
| first_indexed | 2024-03-09T20:31:56Z |
| format | Article |
| id | doaj.art-494f14cc38f445c9936faf2c56bbeacb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:31:56Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-494f14cc38f445c9936faf2c56bbeacb2023-11-23T23:20:48ZengMDPI AGCancers2072-66942022-10-011420503210.3390/cancers14205032Radiotherapy-Related Gene Signature in Prostate CancerParaskevi Kogionou0Sotirios P. Fortis1Maria Goulielmaki2Nicolas Aubert3Panagiota Batsaki4Sotirios Ouzounis5Dionisis Cavouras6Gilles Marodon7Savvas Stokidis8Angelos D. Gritzapis9Constantin N. Baxevanis10Cancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceCancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceCancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceCentre d’Immunologie et Maladies Infectieuses-Paris, CIMI-PARIS, Sorbonne Université, INSERM, CNRS, 75013 Paris, FranceCancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceDepartment of Biomedical Engineering, University of West Attica, 12243 Athens, GreeceDepartment of Biomedical Engineering, University of West Attica, 12243 Athens, GreeceCentre d’Immunologie et Maladies Infectieuses-Paris, CIMI-PARIS, Sorbonne Université, INSERM, CNRS, 75013 Paris, FranceCancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceCancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceCancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 11522 Athens, GreeceRadiotherapy for localized prostate cancer has increased the cure and survival rates of patients. Besides its local tumoricidal effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation, a phenomenon called the abscopal effect. In this study, we performed gene expression analysis on peripheral blood from prostate cancer patients obtained post- radiotherapy and showed that 6 genes, including <i>CCR7</i>, <i>FCGR2B</i>, <i>BTLA</i>, <i>CD6</i>, <i>CD3D</i>, and <i>CD3E</i>, were down-regulated by a range of 1.5–2.5-fold as compared to pre-radiotherapy samples. The expression of the signature consisting of these six genes was also significantly lower post- vs. pre-radiotherapy. These genes are involved in various tumor-promoting immune pathways and their down-regulation post-radiotherapy could be considered beneficial for patients. This is supported by the fact that low mRNA expression levels for the 6-gene signature in the prostate tumor tissue was linked to better survival. Importantly, we report that this 6-gene signature strongly correlated with a favorable prognosis regardless of poor standard clinicopathological parameters (i.e., Gleason score ≥ 8 and T3 (including T3a and T3b). Our pioneering data open the possibility that the 6-gene signature identified herein may have a predictive value, but this requires further long-term studies.https://www.mdpi.com/2072-6694/14/20/5032prostate cancerradiotherapyimmune systemgene-expressionsix-gene signaturepredictive biomarker |
| spellingShingle | Paraskevi Kogionou Sotirios P. Fortis Maria Goulielmaki Nicolas Aubert Panagiota Batsaki Sotirios Ouzounis Dionisis Cavouras Gilles Marodon Savvas Stokidis Angelos D. Gritzapis Constantin N. Baxevanis Radiotherapy-Related Gene Signature in Prostate Cancer Cancers prostate cancer radiotherapy immune system gene-expression six-gene signature predictive biomarker |
| title | Radiotherapy-Related Gene Signature in Prostate Cancer |
| title_full | Radiotherapy-Related Gene Signature in Prostate Cancer |
| title_fullStr | Radiotherapy-Related Gene Signature in Prostate Cancer |
| title_full_unstemmed | Radiotherapy-Related Gene Signature in Prostate Cancer |
| title_short | Radiotherapy-Related Gene Signature in Prostate Cancer |
| title_sort | radiotherapy related gene signature in prostate cancer |
| topic | prostate cancer radiotherapy immune system gene-expression six-gene signature predictive biomarker |
| url | https://www.mdpi.com/2072-6694/14/20/5032 |
| work_keys_str_mv | AT paraskevikogionou radiotherapyrelatedgenesignatureinprostatecancer AT sotiriospfortis radiotherapyrelatedgenesignatureinprostatecancer AT mariagoulielmaki radiotherapyrelatedgenesignatureinprostatecancer AT nicolasaubert radiotherapyrelatedgenesignatureinprostatecancer AT panagiotabatsaki radiotherapyrelatedgenesignatureinprostatecancer AT sotiriosouzounis radiotherapyrelatedgenesignatureinprostatecancer AT dionisiscavouras radiotherapyrelatedgenesignatureinprostatecancer AT gillesmarodon radiotherapyrelatedgenesignatureinprostatecancer AT savvasstokidis radiotherapyrelatedgenesignatureinprostatecancer AT angelosdgritzapis radiotherapyrelatedgenesignatureinprostatecancer AT constantinnbaxevanis radiotherapyrelatedgenesignatureinprostatecancer |