RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes
Response-adaptive randomization designs are becoming increasingly popular in clinical trial practice. In this paper, we present RARtool, a user interface software developed in MATLAB for designing response-adaptive randomized comparative clinical trials with censored time-to-event outcomes. The RARt...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Foundation for Open Access Statistics
2015-08-01
|
| Series: | Journal of Statistical Software |
| Online Access: | http://www.jstatsoft.org/index.php/jss/article/view/2268 |
| _version_ | 1811229987437543424 |
|---|---|
| author | Yevgen Ryeznik Oleksandr Sverdlov Weng Kee Wong |
| author_facet | Yevgen Ryeznik Oleksandr Sverdlov Weng Kee Wong |
| author_sort | Yevgen Ryeznik |
| collection | DOAJ |
| description | Response-adaptive randomization designs are becoming increasingly popular in clinical trial practice. In this paper, we present RARtool, a user interface software developed in MATLAB for designing response-adaptive randomized comparative clinical trials with censored time-to-event outcomes. The RARtool software can compute different types of optimal treatment allocation designs, and it can simulate response-adaptive randomization procedures targeting selected optimal allocations. Through simulations, an investigator can assess design characteristics under a variety of experimental scenarios and select the best procedure for practical implementation. We illustrate the utility of our RARtool software by redesigning a survival trial from the literature. |
| first_indexed | 2024-04-12T10:22:38Z |
| format | Article |
| id | doaj.art-49501246a5af40719b6da5b1d1042aaa |
| institution | Directory Open Access Journal |
| issn | 1548-7660 |
| language | English |
| last_indexed | 2024-04-12T10:22:38Z |
| publishDate | 2015-08-01 |
| publisher | Foundation for Open Access Statistics |
| record_format | Article |
| series | Journal of Statistical Software |
| spelling | doaj.art-49501246a5af40719b6da5b1d1042aaa2022-12-22T03:37:04ZengFoundation for Open Access StatisticsJournal of Statistical Software1548-76602015-08-0166112210.18637/jss.v066.i01872RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event OutcomesYevgen RyeznikOleksandr SverdlovWeng Kee WongResponse-adaptive randomization designs are becoming increasingly popular in clinical trial practice. In this paper, we present RARtool, a user interface software developed in MATLAB for designing response-adaptive randomized comparative clinical trials with censored time-to-event outcomes. The RARtool software can compute different types of optimal treatment allocation designs, and it can simulate response-adaptive randomization procedures targeting selected optimal allocations. Through simulations, an investigator can assess design characteristics under a variety of experimental scenarios and select the best procedure for practical implementation. We illustrate the utility of our RARtool software by redesigning a survival trial from the literature.http://www.jstatsoft.org/index.php/jss/article/view/2268 |
| spellingShingle | Yevgen Ryeznik Oleksandr Sverdlov Weng Kee Wong RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes Journal of Statistical Software |
| title | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes |
| title_full | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes |
| title_fullStr | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes |
| title_full_unstemmed | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes |
| title_short | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes |
| title_sort | rartool a matlab software package for designing response adaptive randomized clinical trials with time to event outcomes |
| url | http://www.jstatsoft.org/index.php/jss/article/view/2268 |
| work_keys_str_mv | AT yevgenryeznik rartoolamatlabsoftwarepackagefordesigningresponseadaptiverandomizedclinicaltrialswithtimetoeventoutcomes AT oleksandrsverdlov rartoolamatlabsoftwarepackagefordesigningresponseadaptiverandomizedclinicaltrialswithtimetoeventoutcomes AT wengkeewong rartoolamatlabsoftwarepackagefordesigningresponseadaptiverandomizedclinicaltrialswithtimetoeventoutcomes |