Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm
Background. COVID-19 disease is the cause of daily morbidity and mortality worldwide due to its high transmissibility and pathogenicity. To date, intravenous immunoglobulin (IVIg) injection has been used as one of the various treatments for this disease. This study aimed to determine the effect of I...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | fas |
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Tabriz University of Medical Sciences
2022-12-01
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| Series: | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| Subjects: | |
| Online Access: | https://mj.tbzmed.ac.ir/PDF/mj-44-403.pdf |
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| author | Farahnoosh Farnood Hamed Valizadeh Khalil Ansarin Sepideh Zununi Vahed Seyyed Sina Hejazian Armin Sadeghi Leila Namvar Farid Rashidi Seyyedeh Mina Hejazian Mohammadreza Ardalan Akbar Sharifi |
| author_facet | Farahnoosh Farnood Hamed Valizadeh Khalil Ansarin Sepideh Zununi Vahed Seyyed Sina Hejazian Armin Sadeghi Leila Namvar Farid Rashidi Seyyedeh Mina Hejazian Mohammadreza Ardalan Akbar Sharifi |
| author_sort | Farahnoosh Farnood |
| collection | DOAJ |
| description | Background. COVID-19 disease is the cause of daily morbidity and mortality worldwide due to its high transmissibility and pathogenicity. To date, intravenous immunoglobulin (IVIg) injection has been used as one of the various treatments for this disease. This study aimed to determine the effect of IVIg injection on the treatment of patients with Coronavirus-induced cytokine storm. Methods. A total of 174 patients with COVID-19 were included in this study based on their clinical characteristics and laboratory findings and were divided into two groups of IVIg recipients and non-recipients according to the treatment they received. Statistical analysis was performed using SPSS version 22.0. A p-value less than 0.05 was considered statistically significant. Results. IVIg was used to treat merely 20 patients and Kaletra and hemoperfusion drugs were used more among IVIg recipient patients (P=0.003 and P=0.001, respectively). COVID-19-positive PCR tests were significantly more frequent among IVIg recipients (P=0.026). The polymorphonuclear neutrophil (PMN) count (P=0.007) and sodium level (P=0.007) were significantly higher in the IVIg recipient group on the first admission day. Moreover, INR levels in the IVIg recipient group were significantly lower on the seventh admission day (P=0.020). The median of total intensive care unit (ICU) duration of hospitalization among IVIg recipients was significantly higher (P=0.001). Conclusion. It seems that the use of IVIg in COVID-19 patients should be further investigated. Practical Implications. IVIg injection could decrease mortality and slightly increase the survival rate among COVID-19 patients. |
| first_indexed | 2024-04-09T14:05:20Z |
| format | Article |
| id | doaj.art-49513c224cfd49e79dd1f72d5a3ba813 |
| institution | Directory Open Access Journal |
| issn | 2783-2031 2783-204X |
| language | fas |
| last_indexed | 2024-04-09T14:05:20Z |
| publishDate | 2022-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| spelling | doaj.art-49513c224cfd49e79dd1f72d5a3ba8132023-05-07T09:42:54ZfasTabriz University of Medical Sciencesمجله پزشکی دانشگاه علوم پزشکی تبریز2783-20312783-204X2022-12-0144540341510.34172/mj.2022.045mj-30885Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine stormFarahnoosh Farnood0Hamed Valizadeh1Khalil Ansarin2Sepideh Zununi Vahed3Seyyed Sina Hejazian4Armin Sadeghi5Leila Namvar6Farid Rashidi7Seyyedeh Mina Hejazian8Mohammadreza Ardalan9Akbar Sharifi10Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranTuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranBackground. COVID-19 disease is the cause of daily morbidity and mortality worldwide due to its high transmissibility and pathogenicity. To date, intravenous immunoglobulin (IVIg) injection has been used as one of the various treatments for this disease. This study aimed to determine the effect of IVIg injection on the treatment of patients with Coronavirus-induced cytokine storm. Methods. A total of 174 patients with COVID-19 were included in this study based on their clinical characteristics and laboratory findings and were divided into two groups of IVIg recipients and non-recipients according to the treatment they received. Statistical analysis was performed using SPSS version 22.0. A p-value less than 0.05 was considered statistically significant. Results. IVIg was used to treat merely 20 patients and Kaletra and hemoperfusion drugs were used more among IVIg recipient patients (P=0.003 and P=0.001, respectively). COVID-19-positive PCR tests were significantly more frequent among IVIg recipients (P=0.026). The polymorphonuclear neutrophil (PMN) count (P=0.007) and sodium level (P=0.007) were significantly higher in the IVIg recipient group on the first admission day. Moreover, INR levels in the IVIg recipient group were significantly lower on the seventh admission day (P=0.020). The median of total intensive care unit (ICU) duration of hospitalization among IVIg recipients was significantly higher (P=0.001). Conclusion. It seems that the use of IVIg in COVID-19 patients should be further investigated. Practical Implications. IVIg injection could decrease mortality and slightly increase the survival rate among COVID-19 patients.https://mj.tbzmed.ac.ir/PDF/mj-44-403.pdfintravenous immunoglobulin (ivig)coronaviruscytokine stormimmunoglobulin g (igg)covid-19 |
| spellingShingle | Farahnoosh Farnood Hamed Valizadeh Khalil Ansarin Sepideh Zununi Vahed Seyyed Sina Hejazian Armin Sadeghi Leila Namvar Farid Rashidi Seyyedeh Mina Hejazian Mohammadreza Ardalan Akbar Sharifi Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm مجله پزشکی دانشگاه علوم پزشکی تبریز intravenous immunoglobulin (ivig) coronavirus cytokine storm immunoglobulin g (igg) covid-19 |
| title | Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm |
| title_full | Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm |
| title_fullStr | Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm |
| title_full_unstemmed | Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm |
| title_short | Injection of intravenous immunoglobulin (IVIg) for the treatment of Coronavirus induced cytokine storm |
| title_sort | injection of intravenous immunoglobulin ivig for the treatment of coronavirus induced cytokine storm |
| topic | intravenous immunoglobulin (ivig) coronavirus cytokine storm immunoglobulin g (igg) covid-19 |
| url | https://mj.tbzmed.ac.ir/PDF/mj-44-403.pdf |
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