Malignant transformation of testicular teratoma to primitive neuroectodermal tumor
Teratoma is a common germ cell tumor that affects young adult males. A small number of testicular teratomas have the potential for malignant transformation along endodermal, ectodermal, or mesodermal lines. The metastatic mixed germ cell tumor we reported consists of the primitive neuroectodermal tu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Urology Annals |
| Subjects: | |
| Online Access: | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=403;epage=406;aulast=Elagi |
| _version_ | 1797988602976665600 |
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| author | Daniyah Elagi Rodney Young Abdulmajeed Dayili |
| author_facet | Daniyah Elagi Rodney Young Abdulmajeed Dayili |
| author_sort | Daniyah Elagi |
| collection | DOAJ |
| description | Teratoma is a common germ cell tumor that affects young adult males. A small number of testicular teratomas have the potential for malignant transformation along endodermal, ectodermal, or mesodermal lines. The metastatic mixed germ cell tumor we reported consists of the primitive neuroectodermal tumor (PNET) with mature teratoma. PNET is a highly aggressive tumor with a poor prognosis given its poor response to standard platinum-based chemotherapy. The primary treatment for PNET is surgical resection. Malignant transformation of teratoma to PNET is a rare phenomenon. Only a few cases of malignant transformation of teratomas to PNET are reported in the literature. Here, we present a rare case of PNET arising in a malignant mixed germ cell tumor in a 23-year-old male who underwent adjuvant adriamycin, cyclophosphamide (VAC) alternating with ifosfamide and etoposide (IE) chemotherapy and retroperitoneal lymph node dissection. |
| first_indexed | 2024-04-11T08:05:46Z |
| format | Article |
| id | doaj.art-49519d12e0e64e21b103ef613411ccd4 |
| institution | Directory Open Access Journal |
| issn | 0974-7796 0974-7834 |
| language | English |
| last_indexed | 2024-04-11T08:05:46Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Urology Annals |
| spelling | doaj.art-49519d12e0e64e21b103ef613411ccd42022-12-22T04:35:32ZengWolters Kluwer Medknow PublicationsUrology Annals0974-77960974-78342022-01-0114440340610.4103/ua.ua_162_21Malignant transformation of testicular teratoma to primitive neuroectodermal tumorDaniyah ElagiRodney YoungAbdulmajeed DayiliTeratoma is a common germ cell tumor that affects young adult males. A small number of testicular teratomas have the potential for malignant transformation along endodermal, ectodermal, or mesodermal lines. The metastatic mixed germ cell tumor we reported consists of the primitive neuroectodermal tumor (PNET) with mature teratoma. PNET is a highly aggressive tumor with a poor prognosis given its poor response to standard platinum-based chemotherapy. The primary treatment for PNET is surgical resection. Malignant transformation of teratoma to PNET is a rare phenomenon. Only a few cases of malignant transformation of teratomas to PNET are reported in the literature. Here, we present a rare case of PNET arising in a malignant mixed germ cell tumor in a 23-year-old male who underwent adjuvant adriamycin, cyclophosphamide (VAC) alternating with ifosfamide and etoposide (IE) chemotherapy and retroperitoneal lymph node dissection.http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=403;epage=406;aulast=Elagimalignant transformation of teratomamixed germ cell tumorprimitive neuroectodermal tumorretroperitoneal lymph node dissection |
| spellingShingle | Daniyah Elagi Rodney Young Abdulmajeed Dayili Malignant transformation of testicular teratoma to primitive neuroectodermal tumor Urology Annals malignant transformation of teratoma mixed germ cell tumor primitive neuroectodermal tumor retroperitoneal lymph node dissection |
| title | Malignant transformation of testicular teratoma to primitive neuroectodermal tumor |
| title_full | Malignant transformation of testicular teratoma to primitive neuroectodermal tumor |
| title_fullStr | Malignant transformation of testicular teratoma to primitive neuroectodermal tumor |
| title_full_unstemmed | Malignant transformation of testicular teratoma to primitive neuroectodermal tumor |
| title_short | Malignant transformation of testicular teratoma to primitive neuroectodermal tumor |
| title_sort | malignant transformation of testicular teratoma to primitive neuroectodermal tumor |
| topic | malignant transformation of teratoma mixed germ cell tumor primitive neuroectodermal tumor retroperitoneal lymph node dissection |
| url | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=403;epage=406;aulast=Elagi |
| work_keys_str_mv | AT daniyahelagi malignanttransformationoftesticularteratomatoprimitiveneuroectodermaltumor AT rodneyyoung malignanttransformationoftesticularteratomatoprimitiveneuroectodermaltumor AT abdulmajeeddayili malignanttransformationoftesticularteratomatoprimitiveneuroectodermaltumor |