Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents. INH is activated by the mycobacterial katG-encoded catalase-peroxidase, forming an acylpyridine fragment that is covalently attached to th...

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Bibliographic Details
Main Authors: Bruno L. Abbadi, Valnês da Silva Rodrigues-Junior, Adilio da Silva Dadda, Kenia Pissinate, Anne D. Villela, Maria M. Campos, Luiz G. de França Lopes, Cristiano V. Bizarro, Pablo Machado, Eduardo H. S. Sousa, Luiz A. Basso
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
pentacyano(isoniazid)ferrate(II) complex
IQG-607
metallodrug
molecular target
isoniazid analog
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00880/full

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