Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases
Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies inv...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/9/3001 |
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| author | Laila Moujir Oliver Callies Pedro M. C. Sousa Farukh Sharopov Ana M. L. Seca |
| author_facet | Laila Moujir Oliver Callies Pedro M. C. Sousa Farukh Sharopov Ana M. L. Seca |
| author_sort | Laila Moujir |
| collection | DOAJ |
| description | Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community. |
| first_indexed | 2024-03-10T20:13:36Z |
| format | Article |
| id | doaj.art-4956d07b21174094be221b9a5fc60789 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T20:13:36Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-4956d07b21174094be221b9a5fc607892023-11-19T22:43:05ZengMDPI AGApplied Sciences2076-34172020-04-01109300110.3390/app10093001Applications of Sesquiterpene Lactones: A Review of Some Potential Success CasesLaila Moujir0Oliver Callies1Pedro M. C. Sousa2Farukh Sharopov3Ana M. L. Seca4Department of Biochemistry, Microbiology, Genetics and Cell Biology, Facultad de Farmacia, Universidad de La Laguna, 38206 San Cristóbal de La Laguna, SpainAbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, GermanyFaculty of Sciences and Technology, University of Azores, 9500-321 Ponta Delgada, PortugalResearch Institution “Chinese-Tajik Innovation Center for Natural Products”, Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, Dushanbe 734063, TajikistancE3c—Centre for Ecology, Evolution and Environmental Changes/Azorean Biodiversity Group & Faculty of Sciences and Technology, University of Azores, Rua Mãe de Deus, 9500-321 Ponta Delgada, PortugalSesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit a broad spectrum of biological effects and several of them are already commercially available, such as artemisinin. Here the most recent and impactful results of in vivo, preclinical and clinical studies involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) are presented and discussed, along with some of their derivatives. In the authors’ opinion, these compounds have been neglected compared to others, although they could be of great use in developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer and anti-inflammatory effects, acting on various targets. Moreover, they exhibit antifungal, anxiolytic, analgesic, and antitrypanosomal activities. Several studies discussed here clearly show the potential that some of them have in combination therapy, as sensitizing agents to facilitate and enhance the action of drugs in clinical use. The derivatives show greater pharmacological value since they have better pharmacokinetics, stability, potency, and/or selectivity. All these natural terpenoids and their derivatives exhibit properties that invite further research by the scientific community.https://www.mdpi.com/2076-3417/10/9/3001Asteraceaesesquiterpene lactonesalantolactonearglabinparthenolidethapsigargin |
| spellingShingle | Laila Moujir Oliver Callies Pedro M. C. Sousa Farukh Sharopov Ana M. L. Seca Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases Applied Sciences Asteraceae sesquiterpene lactones alantolactone arglabin parthenolide thapsigargin |
| title | Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases |
| title_full | Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases |
| title_fullStr | Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases |
| title_full_unstemmed | Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases |
| title_short | Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases |
| title_sort | applications of sesquiterpene lactones a review of some potential success cases |
| topic | Asteraceae sesquiterpene lactones alantolactone arglabin parthenolide thapsigargin |
| url | https://www.mdpi.com/2076-3417/10/9/3001 |
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