Role of Senescent Cells in Cutaneous Wound Healing
Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes, tumorigenesis, development, and wound repair amongst other processes and pathologies. Recent findings reveal that senescent cells can both promote a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/11/12/1731 |
| _version_ | 1797461345397899264 |
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| author | Allison M. Andrade Mingda Sun Nathan S. Gasek Geneva R. Hargis Roshanak Sharafieh Ming Xu |
| author_facet | Allison M. Andrade Mingda Sun Nathan S. Gasek Geneva R. Hargis Roshanak Sharafieh Ming Xu |
| author_sort | Allison M. Andrade |
| collection | DOAJ |
| description | Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes, tumorigenesis, development, and wound repair amongst other processes and pathologies. Recent findings reveal that senescent cells can both promote and inhibit cutaneous wound healing processes. Relating senescent cells in acute and chronic wounds will help to clarify their role in wound healing processes and inform our understanding of senescent cell heterogeneity. To clarify this apparent contradiction and guide future research and therapeutic development, we will review the rapidly growing field of cellular senescence and its role in wound healing biology. |
| first_indexed | 2024-03-09T17:19:06Z |
| format | Article |
| id | doaj.art-49573728084846ebac911fc5ed5a3beb |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T17:19:06Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-49573728084846ebac911fc5ed5a3beb2023-11-24T13:22:28ZengMDPI AGBiology2079-77372022-11-011112173110.3390/biology11121731Role of Senescent Cells in Cutaneous Wound HealingAllison M. Andrade0Mingda Sun1Nathan S. Gasek2Geneva R. Hargis3Roshanak Sharafieh4Ming Xu5UConn Center on Aging, UConn Health, Farmington, CT 06030, USAUConn Center on Aging, UConn Health, Farmington, CT 06030, USAUConn Center on Aging, UConn Health, Farmington, CT 06030, USAUConn School of Medicine, UConn Health, Farmington, CT 06030, USADepartment of Surgery, UConn Health, Farmington, CT 06030, USAUConn Center on Aging, UConn Health, Farmington, CT 06030, USACellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes, tumorigenesis, development, and wound repair amongst other processes and pathologies. Recent findings reveal that senescent cells can both promote and inhibit cutaneous wound healing processes. Relating senescent cells in acute and chronic wounds will help to clarify their role in wound healing processes and inform our understanding of senescent cell heterogeneity. To clarify this apparent contradiction and guide future research and therapeutic development, we will review the rapidly growing field of cellular senescence and its role in wound healing biology.https://www.mdpi.com/2079-7737/11/12/1731agingcellular senescenceheterogeneitywound healingacute cutaneous woundschronic cutaneous wounds |
| spellingShingle | Allison M. Andrade Mingda Sun Nathan S. Gasek Geneva R. Hargis Roshanak Sharafieh Ming Xu Role of Senescent Cells in Cutaneous Wound Healing Biology aging cellular senescence heterogeneity wound healing acute cutaneous wounds chronic cutaneous wounds |
| title | Role of Senescent Cells in Cutaneous Wound Healing |
| title_full | Role of Senescent Cells in Cutaneous Wound Healing |
| title_fullStr | Role of Senescent Cells in Cutaneous Wound Healing |
| title_full_unstemmed | Role of Senescent Cells in Cutaneous Wound Healing |
| title_short | Role of Senescent Cells in Cutaneous Wound Healing |
| title_sort | role of senescent cells in cutaneous wound healing |
| topic | aging cellular senescence heterogeneity wound healing acute cutaneous wounds chronic cutaneous wounds |
| url | https://www.mdpi.com/2079-7737/11/12/1731 |
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