A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster

A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster

The use of transposons to create mutations has been the cornerstone of Drosophila genetics in the past few decades. Second-site mutations caused by transpositions are often devoid of transposons and thereby affect subsequent analyses. In a P-element mutagenesis screen, a second site mutation was ide...

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Bibliographic Details
Main Authors: Rakesh Mishra, Rohit Kunar, Lolitika Mandal, Debasmita Pankaj Alone, Shanti Chandrasekharan, Anand Krishna Tiwari, Madhu Gwaldas Tapadia, Ashim Mukherjee, Jagat Kumar Roy
Format: Article
Language:English
Published: Oxford University Press 2020-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
dcp2
tumor suppressor
drosophila
genetic mapping
forward genetics
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401501

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