Oligodendrocyte ablation as a tool to study demyelinating diseases
Multiple sclerosis (MS) is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte (OL) loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=886;epage=889;aulast=Pajoohesh-Ganji |
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| author | Ahdeah Pajoohesh-Ganji Robert H Miller |
| author_facet | Ahdeah Pajoohesh-Ganji Robert H Miller |
| author_sort | Ahdeah Pajoohesh-Ganji |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte (OL) loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause remains unknown. It is also unclear whether OL apoptosis precedes the inflammation or whether the local inflammation is the cause of OL death and demyelination. This review briefly discusses several models that have been developed to specifically ablate oligodendrocytes in an effort to separate the effects of demyelination from inflammation. |
| first_indexed | 2024-12-22T15:13:18Z |
| format | Article |
| id | doaj.art-4959a7e25f264107974f940b364c6464 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-22T15:13:18Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-4959a7e25f264107974f940b364c64642022-12-21T18:21:49ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-0111688688910.4103/1673-5374.184451Oligodendrocyte ablation as a tool to study demyelinating diseasesAhdeah Pajoohesh-GanjiRobert H MillerMultiple sclerosis (MS) is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte (OL) loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause remains unknown. It is also unclear whether OL apoptosis precedes the inflammation or whether the local inflammation is the cause of OL death and demyelination. This review briefly discusses several models that have been developed to specifically ablate oligodendrocytes in an effort to separate the effects of demyelination from inflammation.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=886;epage=889;aulast=Pajoohesh-Ganjimultiple sclerosis; oligodendrocyte; apoptosis; demyelination; optic neuritis |
| spellingShingle | Ahdeah Pajoohesh-Ganji Robert H Miller Oligodendrocyte ablation as a tool to study demyelinating diseases Neural Regeneration Research multiple sclerosis; oligodendrocyte; apoptosis; demyelination; optic neuritis |
| title | Oligodendrocyte ablation as a tool to study demyelinating diseases |
| title_full | Oligodendrocyte ablation as a tool to study demyelinating diseases |
| title_fullStr | Oligodendrocyte ablation as a tool to study demyelinating diseases |
| title_full_unstemmed | Oligodendrocyte ablation as a tool to study demyelinating diseases |
| title_short | Oligodendrocyte ablation as a tool to study demyelinating diseases |
| title_sort | oligodendrocyte ablation as a tool to study demyelinating diseases |
| topic | multiple sclerosis; oligodendrocyte; apoptosis; demyelination; optic neuritis |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=886;epage=889;aulast=Pajoohesh-Ganji |
| work_keys_str_mv | AT ahdeahpajooheshganji oligodendrocyteablationasatooltostudydemyelinatingdiseases AT roberthmiller oligodendrocyteablationasatooltostudydemyelinatingdiseases |