Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0
Personalized treatment is defined as choosing the “right treatment for the right person at the right time.” Although psychiatry has not yet reached this level of precision, we are on the way thanks to recent technological developments that may aid to detect plausible molecular and genetic markers. A...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00641/full |
| _version_ | 1819179178386259968 |
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| author | Estela Salagre Seetal Dodd Seetal Dodd Seetal Dodd Alberto Aedo Alberto Aedo Adriane Rosa Adriane Rosa Adriane Rosa Silvia Amoretti Justo Pinzon Maria Reinares Michael Berk Michael Berk Michael Berk Michael Berk Flavio Pereira Kapczinski Eduard Vieta Iria Grande |
| author_facet | Estela Salagre Seetal Dodd Seetal Dodd Seetal Dodd Alberto Aedo Alberto Aedo Adriane Rosa Adriane Rosa Adriane Rosa Silvia Amoretti Justo Pinzon Maria Reinares Michael Berk Michael Berk Michael Berk Michael Berk Flavio Pereira Kapczinski Eduard Vieta Iria Grande |
| author_sort | Estela Salagre |
| collection | DOAJ |
| description | Personalized treatment is defined as choosing the “right treatment for the right person at the right time.” Although psychiatry has not yet reached this level of precision, we are on the way thanks to recent technological developments that may aid to detect plausible molecular and genetic markers. At the moment there are some models that are contributing to precision psychiatry through the concept of staging. While staging was initially presented as a way to categorize patients according to clinical presentation, course, and illness severity, current staging models integrate multiple levels of information that can help to define each patient's characteristics, severity, and prognosis in a more precise and individualized way. Moreover, staging might serve as the foundation to create a clinical decision-making algorithm on the basis of the patient's stage. In this review we will summarize the evolution of the bipolar disorder staging model in relation to the new discoveries on the neurobiology of bipolar disorder. Furthermore, we will discuss how the latest and future progress in psychiatry might transform current staging models into precision staging models. |
| first_indexed | 2024-12-22T21:54:19Z |
| format | Article |
| id | doaj.art-495adf1b0dc3459ea7a8cc6c9cf611fc |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T21:54:19Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-495adf1b0dc3459ea7a8cc6c9cf611fc2022-12-21T18:11:17ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-11-01910.3389/fpsyt.2018.00641418300Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0Estela Salagre0Seetal Dodd1Seetal Dodd2Seetal Dodd3Alberto Aedo4Alberto Aedo5Adriane Rosa6Adriane Rosa7Adriane Rosa8Silvia Amoretti9Justo Pinzon10Maria Reinares11Michael Berk12Michael Berk13Michael Berk14Michael Berk15Flavio Pereira Kapczinski16Eduard Vieta17Iria Grande18Barcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, SpainIMPACT Strategic Research Centre, Barwon Health, Deakin University, Geelong, VIC, AustraliaDepartment of Psychiatry, University of Melbourne, Parkville, VIC, AustraliaOrygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, AustraliaBarcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, SpainBipolar Disorders Unit, Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileLaboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilPostgraduate Program: Psychiatry and Behavioral Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilDepartment of Pharmacology and Postgraduate Program: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilBarcelona Clínic Schizophrenia Unit, Hospital Clinic de Barcelona, CIBERSAM, Barcelona, SpainBarcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, SpainBarcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, SpainIMPACT Strategic Research Centre, Barwon Health, Deakin University, Geelong, VIC, AustraliaDepartment of Psychiatry, University of Melbourne, Parkville, VIC, AustraliaOrygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia0Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia1Department of Psychiatry & Behavioral Neurosciences, Mcmaster University, Hamilton, ON, CanadaBarcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, SpainBarcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, SpainPersonalized treatment is defined as choosing the “right treatment for the right person at the right time.” Although psychiatry has not yet reached this level of precision, we are on the way thanks to recent technological developments that may aid to detect plausible molecular and genetic markers. At the moment there are some models that are contributing to precision psychiatry through the concept of staging. While staging was initially presented as a way to categorize patients according to clinical presentation, course, and illness severity, current staging models integrate multiple levels of information that can help to define each patient's characteristics, severity, and prognosis in a more precise and individualized way. Moreover, staging might serve as the foundation to create a clinical decision-making algorithm on the basis of the patient's stage. In this review we will summarize the evolution of the bipolar disorder staging model in relation to the new discoveries on the neurobiology of bipolar disorder. Furthermore, we will discuss how the latest and future progress in psychiatry might transform current staging models into precision staging models.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00641/fullbipolar disorderstagingbiomarkerspersonalized psychiatryprevention |
| spellingShingle | Estela Salagre Seetal Dodd Seetal Dodd Seetal Dodd Alberto Aedo Alberto Aedo Adriane Rosa Adriane Rosa Adriane Rosa Silvia Amoretti Justo Pinzon Maria Reinares Michael Berk Michael Berk Michael Berk Michael Berk Flavio Pereira Kapczinski Eduard Vieta Iria Grande Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0 Frontiers in Psychiatry bipolar disorder staging biomarkers personalized psychiatry prevention |
| title | Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0 |
| title_full | Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0 |
| title_fullStr | Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0 |
| title_full_unstemmed | Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0 |
| title_short | Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0 |
| title_sort | toward precision psychiatry in bipolar disorder staging 2 0 |
| topic | bipolar disorder staging biomarkers personalized psychiatry prevention |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00641/full |
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