Advanced Hydrogels as Wound Dressings
Skin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/8/1169 |
| _version_ | 1797558933044330496 |
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| author | Shima Tavakoli Agnes S. Klar |
| author_facet | Shima Tavakoli Agnes S. Klar |
| author_sort | Shima Tavakoli |
| collection | DOAJ |
| description | Skin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering, in recent years, to develop new skin substitutes. Among them, hydrogels are one of the candidates with most potential to mimic the native skin microenvironment, due to their porous and hydrated molecular structure. They can be applied as a permanent or temporary dressing for different wounds to support the regeneration and healing of the injured epidermis, dermis, or both. Based on the material used for their fabrication, hydrogels can be subdivided into two main groups—natural and synthetic. Moreover, hydrogels can be reinforced by incorporating nanoparticles to obtain “in situ” hybrid hydrogels, showing superior properties and tailored functionality. In addition, different sensors can be embedded in hydrogel wound dressings to provide real-time information about the wound environment. This review focuses on the most recent developments in the field of hydrogel-based skin substitutes for skin replacement. In particular, we discuss the synthesis, fabrication, and biomedical application of novel “smart” hydrogels. |
| first_indexed | 2024-03-10T17:38:28Z |
| format | Article |
| id | doaj.art-495b0a3813b04497a7d858892ab9cd8f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T17:38:28Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-495b0a3813b04497a7d858892ab9cd8f2023-11-20T09:45:58ZengMDPI AGBiomolecules2218-273X2020-08-01108116910.3390/biom10081169Advanced Hydrogels as Wound DressingsShima Tavakoli0Agnes S. Klar1Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, IranTissue Biology Research Unit, University Children’s Hospital Zurich, University of Zurich, 75, 8032 Zurich, SwitzerlandSkin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering, in recent years, to develop new skin substitutes. Among them, hydrogels are one of the candidates with most potential to mimic the native skin microenvironment, due to their porous and hydrated molecular structure. They can be applied as a permanent or temporary dressing for different wounds to support the regeneration and healing of the injured epidermis, dermis, or both. Based on the material used for their fabrication, hydrogels can be subdivided into two main groups—natural and synthetic. Moreover, hydrogels can be reinforced by incorporating nanoparticles to obtain “in situ” hybrid hydrogels, showing superior properties and tailored functionality. In addition, different sensors can be embedded in hydrogel wound dressings to provide real-time information about the wound environment. This review focuses on the most recent developments in the field of hydrogel-based skin substitutes for skin replacement. In particular, we discuss the synthesis, fabrication, and biomedical application of novel “smart” hydrogels.https://www.mdpi.com/2218-273X/10/8/1169tissue engineeringskin substitutessprayable “smart” hydrogels“in situ” forming hydrogelswound dressings with integrated sensorsregenerative medicine |
| spellingShingle | Shima Tavakoli Agnes S. Klar Advanced Hydrogels as Wound Dressings Biomolecules tissue engineering skin substitutes sprayable “smart” hydrogels “in situ” forming hydrogels wound dressings with integrated sensors regenerative medicine |
| title | Advanced Hydrogels as Wound Dressings |
| title_full | Advanced Hydrogels as Wound Dressings |
| title_fullStr | Advanced Hydrogels as Wound Dressings |
| title_full_unstemmed | Advanced Hydrogels as Wound Dressings |
| title_short | Advanced Hydrogels as Wound Dressings |
| title_sort | advanced hydrogels as wound dressings |
| topic | tissue engineering skin substitutes sprayable “smart” hydrogels “in situ” forming hydrogels wound dressings with integrated sensors regenerative medicine |
| url | https://www.mdpi.com/2218-273X/10/8/1169 |
| work_keys_str_mv | AT shimatavakoli advancedhydrogelsaswounddressings AT agnessklar advancedhydrogelsaswounddressings |