Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study
Abstract Introduction Bronchial thermoplasty (BT) is a bronchoscopic procedure that involves the delivery of thermal radiofrequency energy to the bronchial wall for treating severe asthma. It has been suggested that too many radiofrequency activations could induce serious adverse events (SAEs) at an...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-11-01
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| Series: | Pulmonary Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s41030-019-00103-7 |
| _version_ | 1818555396146593792 |
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| author | Shota Yamamoto Motoyasu Iikura Tamaki Kakuwa Yoshie Tsujimoto Sachi Matsubayashi Naoko Nagano Tomoyuki Suzuki Keita Sakamoto Konomi Kobayashi Ayako Shiozawa Masao Hashimoto Satoru Ishii Manabu Suzuki Shinyu Izumi Masayuki Hojo Terumitsu Hasebe Haruhito Sugiyama |
| author_facet | Shota Yamamoto Motoyasu Iikura Tamaki Kakuwa Yoshie Tsujimoto Sachi Matsubayashi Naoko Nagano Tomoyuki Suzuki Keita Sakamoto Konomi Kobayashi Ayako Shiozawa Masao Hashimoto Satoru Ishii Manabu Suzuki Shinyu Izumi Masayuki Hojo Terumitsu Hasebe Haruhito Sugiyama |
| author_sort | Shota Yamamoto |
| collection | DOAJ |
| description | Abstract Introduction Bronchial thermoplasty (BT) is a bronchoscopic procedure that involves the delivery of thermal radiofrequency energy to the bronchial wall for treating severe asthma. It has been suggested that too many radiofrequency activations could induce serious adverse events (SAEs) at an early stage. We aimed to examine the number of radiofrequency activations at each session and early lung function changes from baseline to determine whether these are related to SAEs. Methods We retrospectively investigated 13 consecutive patients who underwent three sessions each of BT for severe asthma from February 2015 to January 2016. Lung function tests were performed on the day before and after each BT procedure. Since we compared the number of activations and lung function changes from baseline after each session, a total of 39 sessions were reviewed. The relationship between the number of radiofrequency activations and each lung function change from baseline was also examined by linear regression analysis. Results A total of 10 SAEs (4 of pneumonia, 3 of atelectasis, 2 of bronchial asthma exacerbation and 1 of hemoptysis) were observed following the 39 BT sessions. When we compared sessions with and without SAEs, there were no differences in the number of activations (mean ± SD, 71.5 ± 28.6 times in sessions with SAEs; 66.5 ± 25.1 times in sessions without SAEs; p = 0.772) and lung function changes (mean changes in FVC/%FVC/FEV1/%FEV1/%PEF from baseline; − 0.49 l/− 14.2%/− 0.36 l/− 11.7%/− 9.6% in sessions with SAEs; − 0.43 l/− 13.3%/− 0.34 l/− 12.1%/− 9.4% in sessions without SAEs; p > 0.05 for all the above). Increase in the number of activations correlated with decreased FEV1 (R 2 = 0.17, p = 0.0088) and %FEV1 (R 2 = 0.11, p = 0.0357). Conclusions Increase in the number of radiofrequency activations during BT is related to a decrease in FEV1 and %FEV1 from baseline. The number of radiofrequency activations, however, is not associated with SAEs after BT. |
| first_indexed | 2024-12-12T09:52:55Z |
| format | Article |
| id | doaj.art-495bf9f6a864476093b0af866a47bd1b |
| institution | Directory Open Access Journal |
| issn | 2364-1754 2364-1746 |
| language | English |
| last_indexed | 2024-12-12T09:52:55Z |
| publishDate | 2019-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pulmonary Therapy |
| spelling | doaj.art-495bf9f6a864476093b0af866a47bd1b2022-12-22T00:28:13ZengAdis, Springer HealthcarePulmonary Therapy2364-17542364-17462019-11-015222123310.1007/s41030-019-00103-7Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control StudyShota Yamamoto0Motoyasu Iikura1Tamaki Kakuwa2Yoshie Tsujimoto3Sachi Matsubayashi4Naoko Nagano5Tomoyuki Suzuki6Keita Sakamoto7Konomi Kobayashi8Ayako Shiozawa9Masao Hashimoto10Satoru Ishii11Manabu Suzuki12Shinyu Izumi13Masayuki Hojo14Terumitsu Hasebe15Haruhito Sugiyama16Department of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineRespiratory Disease Center, NTT Medical Center TokyoDepartment of Radiology, Tokai University Hachioji Hospital, Tokai University School of MedicineDepartment of Respiratory Medicine, National Center for Global Health and MedicineAbstract Introduction Bronchial thermoplasty (BT) is a bronchoscopic procedure that involves the delivery of thermal radiofrequency energy to the bronchial wall for treating severe asthma. It has been suggested that too many radiofrequency activations could induce serious adverse events (SAEs) at an early stage. We aimed to examine the number of radiofrequency activations at each session and early lung function changes from baseline to determine whether these are related to SAEs. Methods We retrospectively investigated 13 consecutive patients who underwent three sessions each of BT for severe asthma from February 2015 to January 2016. Lung function tests were performed on the day before and after each BT procedure. Since we compared the number of activations and lung function changes from baseline after each session, a total of 39 sessions were reviewed. The relationship between the number of radiofrequency activations and each lung function change from baseline was also examined by linear regression analysis. Results A total of 10 SAEs (4 of pneumonia, 3 of atelectasis, 2 of bronchial asthma exacerbation and 1 of hemoptysis) were observed following the 39 BT sessions. When we compared sessions with and without SAEs, there were no differences in the number of activations (mean ± SD, 71.5 ± 28.6 times in sessions with SAEs; 66.5 ± 25.1 times in sessions without SAEs; p = 0.772) and lung function changes (mean changes in FVC/%FVC/FEV1/%FEV1/%PEF from baseline; − 0.49 l/− 14.2%/− 0.36 l/− 11.7%/− 9.6% in sessions with SAEs; − 0.43 l/− 13.3%/− 0.34 l/− 12.1%/− 9.4% in sessions without SAEs; p > 0.05 for all the above). Increase in the number of activations correlated with decreased FEV1 (R 2 = 0.17, p = 0.0088) and %FEV1 (R 2 = 0.11, p = 0.0357). Conclusions Increase in the number of radiofrequency activations during BT is related to a decrease in FEV1 and %FEV1 from baseline. The number of radiofrequency activations, however, is not associated with SAEs after BT.http://link.springer.com/article/10.1007/s41030-019-00103-7Bronchial asthmaBronchial thermoplastyLung function testsSerious adverse events |
| spellingShingle | Shota Yamamoto Motoyasu Iikura Tamaki Kakuwa Yoshie Tsujimoto Sachi Matsubayashi Naoko Nagano Tomoyuki Suzuki Keita Sakamoto Konomi Kobayashi Ayako Shiozawa Masao Hashimoto Satoru Ishii Manabu Suzuki Shinyu Izumi Masayuki Hojo Terumitsu Hasebe Haruhito Sugiyama Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study Pulmonary Therapy Bronchial asthma Bronchial thermoplasty Lung function tests Serious adverse events |
| title | Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study |
| title_full | Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study |
| title_fullStr | Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study |
| title_full_unstemmed | Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study |
| title_short | Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study |
| title_sort | can the number of radiofrequency activations predict serious adverse events after bronchial thermoplasty a retrospective case control study |
| topic | Bronchial asthma Bronchial thermoplasty Lung function tests Serious adverse events |
| url | http://link.springer.com/article/10.1007/s41030-019-00103-7 |
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