Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease
Abstract The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in relation to either advanced AD-like disease or hippoc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11153-4 |
| _version_ | 1831517888607944704 |
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| author | Matias Mugnaini Diana Polania Yannina Diaz Marcelo Ezquer Fernando Ezquer Robert M. J. Deacon Patricia Cogram Emilio Kropff |
| author_facet | Matias Mugnaini Diana Polania Yannina Diaz Marcelo Ezquer Fernando Ezquer Robert M. J. Deacon Patricia Cogram Emilio Kropff |
| author_sort | Matias Mugnaini |
| collection | DOAJ |
| description | Abstract The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in relation to either advanced AD-like disease or hippocampal lesion, opening the way to investigate how the function of hippocampal networks affects behavior across AD stages. However, no characterization of hippocampal electrophysiology exists in this species. Here we describe in young, healthy specimens the activity of neurons and local field potential rhythms during spatial navigation tasks with and without objects. Our findings show similarities between the Octodon degus and laboratory rodents. First, place cells with characteristics similar to those found in rats and mice exist in the CA1 subfield of the Octodon degus. Second, the introduction of objects elicits novelty-related exploration and an increase in activity of CA1 cells, with location specific and unspecific components. Third, oscillations of the local field potential are organized according to their spectral content into bands similar to those found in laboratory rodents. These results suggest a common framework of underlying mechanisms, opening the way to future studies of hippocampal dysfunction in this species associated to aging and disease. |
| first_indexed | 2024-12-12T01:22:00Z |
| format | Article |
| id | doaj.art-495e7d45e4dc417c892dacd7bb1a3553 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T01:22:00Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-495e7d45e4dc417c892dacd7bb1a35532022-12-22T00:43:12ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-11153-4Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s diseaseMatias Mugnaini0Diana Polania1Yannina Diaz2Marcelo Ezquer3Fernando Ezquer4Robert M. J. Deacon5Patricia Cogram6Emilio Kropff7Leloir Institute—IIBBA, CONICETDepartment of Ecological Sciences, Institute of Ecology and Biodiversity, Faculty of Sciences, Universidad de ChileLeloir Institute—IIBBA, CONICETCentro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del DesarrolloCentro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del DesarrolloDepartment of Ecological Sciences, Institute of Ecology and Biodiversity, Faculty of Sciences, Universidad de ChileDepartment of Ecological Sciences, Institute of Ecology and Biodiversity, Faculty of Sciences, Universidad de ChileLeloir Institute—IIBBA, CONICETAbstract The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in relation to either advanced AD-like disease or hippocampal lesion, opening the way to investigate how the function of hippocampal networks affects behavior across AD stages. However, no characterization of hippocampal electrophysiology exists in this species. Here we describe in young, healthy specimens the activity of neurons and local field potential rhythms during spatial navigation tasks with and without objects. Our findings show similarities between the Octodon degus and laboratory rodents. First, place cells with characteristics similar to those found in rats and mice exist in the CA1 subfield of the Octodon degus. Second, the introduction of objects elicits novelty-related exploration and an increase in activity of CA1 cells, with location specific and unspecific components. Third, oscillations of the local field potential are organized according to their spectral content into bands similar to those found in laboratory rodents. These results suggest a common framework of underlying mechanisms, opening the way to future studies of hippocampal dysfunction in this species associated to aging and disease.https://doi.org/10.1038/s41598-022-11153-4 |
| spellingShingle | Matias Mugnaini Diana Polania Yannina Diaz Marcelo Ezquer Fernando Ezquer Robert M. J. Deacon Patricia Cogram Emilio Kropff Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease Scientific Reports |
| title | Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease |
| title_full | Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease |
| title_fullStr | Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease |
| title_full_unstemmed | Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease |
| title_short | Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease |
| title_sort | spatial maps and oscillations in the healthy hippocampus of octodon degus a natural model of sporadic alzheimer s disease |
| url | https://doi.org/10.1038/s41598-022-11153-4 |
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