Dysregulation and detection methods of EGFR in oral cancer. A narrative review.
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, with an intracellular domain and tyrosine kinase function (TK) involved in cell proliferation. Dysfunctions in EGFR signaling pathways have been associated with oral malignant tumors such as oral squamous cell carcinoma (OSCC)....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidad de Concepción.
2016-11-01
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| Series: | Journal of Oral Research |
| Subjects: | |
| Online Access: | http://www.joralres.com/index.php/JOR/article/view/270/260 |
| _version_ | 1811312477137272832 |
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| author | Carolina Somarriva Alejandra Fernández Jorge Candia Javier Campos Daniela Albers Jorge Briceño |
| author_facet | Carolina Somarriva Alejandra Fernández Jorge Candia Javier Campos Daniela Albers Jorge Briceño |
| author_sort | Carolina Somarriva |
| collection | DOAJ |
| description | Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, with an intracellular domain and tyrosine kinase function (TK) involved in cell proliferation. Dysfunctions in EGFR signaling pathways have been associated with oral malignant tumors such as oral squamous cell carcinoma (OSCC). Dysfunctions of EGFR may result from: increased EGF ligand; EGFR overexpression and copy number gain of the EGFR gene (EGFR CNG); EGFR mutations; failure in the downregulation of EGFR; and EGFR crosstalk. Of these alterations, overexpression of EGFR is by far the most studied dysfunction in OSCC. Clinicians should identify possible alterations of EGFR in the oral mucosa of patients, as EGFR can act as a biomarker for the diagnosis and prognosis of OSCC. Currently, there are several methods and techniques for detecting EGFR. Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR), are used to identify overexpression of EGFR, EGFR CNG and EGFR mutations, respectively. Detection of EGFR as a biomarker is key to identify any oral malignant transformation. Consequently, it becomes imperative to implement a non-invasive and inexpensive method of early diagnosis for OSCC in clinical practice. |
| first_indexed | 2024-04-13T10:38:00Z |
| format | Article |
| id | doaj.art-495eb1f90ec94c23b366d5129924b7a2 |
| institution | Directory Open Access Journal |
| issn | 0719-2460 0719-2479 |
| language | English |
| last_indexed | 2024-04-13T10:38:00Z |
| publishDate | 2016-11-01 |
| publisher | Universidad de Concepción. |
| record_format | Article |
| series | Journal of Oral Research |
| spelling | doaj.art-495eb1f90ec94c23b366d5129924b7a22022-12-22T02:50:00ZengUniversidad de Concepción.Journal of Oral Research0719-24600719-24792016-11-015728529210.17126/joralres.2016.057Dysregulation and detection methods of EGFR in oral cancer. A narrative review.Carolina Somarriva0Alejandra Fernández1Jorge Candia2Javier Campos3Daniela Albers4Jorge Briceño5Facultad de Odontología. Universidad Andres Bello. Chile.Facultad de Odontología. Universidad Andres Bello. Chile. Centro de Investigación Biomédica. Universidad de Los Andes, Chile.Facultad de Odontología. Universidad Andres Bello. Chile.Centro de Investigación Biomédica. Universidad de Los Andes, Chile.Centro de Investigación Biomédica. Universidad de Los Andes, Chile. Facultad de Odontología. Universidad Mayor, Chile.Facultad de Odontología. Universidad Andres Bello. Chile.Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, with an intracellular domain and tyrosine kinase function (TK) involved in cell proliferation. Dysfunctions in EGFR signaling pathways have been associated with oral malignant tumors such as oral squamous cell carcinoma (OSCC). Dysfunctions of EGFR may result from: increased EGF ligand; EGFR overexpression and copy number gain of the EGFR gene (EGFR CNG); EGFR mutations; failure in the downregulation of EGFR; and EGFR crosstalk. Of these alterations, overexpression of EGFR is by far the most studied dysfunction in OSCC. Clinicians should identify possible alterations of EGFR in the oral mucosa of patients, as EGFR can act as a biomarker for the diagnosis and prognosis of OSCC. Currently, there are several methods and techniques for detecting EGFR. Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR), are used to identify overexpression of EGFR, EGFR CNG and EGFR mutations, respectively. Detection of EGFR as a biomarker is key to identify any oral malignant transformation. Consequently, it becomes imperative to implement a non-invasive and inexpensive method of early diagnosis for OSCC in clinical practice.http://www.joralres.com/index.php/JOR/article/view/270/260Epidermal Growth Factor ReceptorMouth NeoplasmMutation. |
| spellingShingle | Carolina Somarriva Alejandra Fernández Jorge Candia Javier Campos Daniela Albers Jorge Briceño Dysregulation and detection methods of EGFR in oral cancer. A narrative review. Journal of Oral Research Epidermal Growth Factor Receptor Mouth Neoplasm Mutation. |
| title | Dysregulation and detection methods of EGFR in oral cancer. A narrative review. |
| title_full | Dysregulation and detection methods of EGFR in oral cancer. A narrative review. |
| title_fullStr | Dysregulation and detection methods of EGFR in oral cancer. A narrative review. |
| title_full_unstemmed | Dysregulation and detection methods of EGFR in oral cancer. A narrative review. |
| title_short | Dysregulation and detection methods of EGFR in oral cancer. A narrative review. |
| title_sort | dysregulation and detection methods of egfr in oral cancer a narrative review |
| topic | Epidermal Growth Factor Receptor Mouth Neoplasm Mutation. |
| url | http://www.joralres.com/index.php/JOR/article/view/270/260 |
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