Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy
Abstract Background The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. Main body This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-07-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43094-020-00048-8 |
| _version_ | 1818082186417405952 |
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| author | Heba A. Ibrahim Hanan M. Refaat |
| author_facet | Heba A. Ibrahim Hanan M. Refaat |
| author_sort | Heba A. Ibrahim |
| collection | DOAJ |
| description | Abstract Background The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. Main body This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus. Conclusion The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds. |
| first_indexed | 2024-12-10T19:18:06Z |
| format | Article |
| id | doaj.art-495eef56639644cc923e7e17352e20ce |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-12-10T19:18:06Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-495eef56639644cc923e7e17352e20ce2022-12-22T01:36:32ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532020-07-016112010.1186/s43094-020-00048-8Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapyHeba A. Ibrahim0Hanan M. Refaat1Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in EgyptAbstract Background The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. Main body This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus. Conclusion The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds.http://link.springer.com/article/10.1186/s43094-020-00048-8HeterocyclicBenizimidazoleAnticancerCytotoxic effect |
| spellingShingle | Heba A. Ibrahim Hanan M. Refaat Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy Future Journal of Pharmaceutical Sciences Heterocyclic Benizimidazole Anticancer Cytotoxic effect |
| title | Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy |
| title_full | Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy |
| title_fullStr | Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy |
| title_full_unstemmed | Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy |
| title_short | Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy |
| title_sort | versatile mechanisms of 2 substituted benzimidazoles in targeted cancer therapy |
| topic | Heterocyclic Benizimidazole Anticancer Cytotoxic effect |
| url | http://link.springer.com/article/10.1186/s43094-020-00048-8 |
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