Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review
Lan Liu,1 Meizuo Zhong,1,2 Xuan Zhou,3 Fanhua Kang,4 Yong Long,1 Junfeng Li1 1Department of Oncology, Xiangya Changde Hospital, Changde, Hunan, People’s Republic of China; 2Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 3Department of...
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| Format: | Article |
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Dove Medical Press
2024-02-01
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| Series: | OncoTargets and Therapy |
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| Online Access: | https://www.dovepress.com/treatment-of-abdominal-desmoplastic-small-round-cell-tumor-induces-acu-peer-reviewed-fulltext-article-OTT |
| _version_ | 1797279381999058944 |
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| author | Liu L Zhong M Zhou X Kang F Long Y Li J |
| author_facet | Liu L Zhong M Zhou X Kang F Long Y Li J |
| author_sort | Liu L |
| collection | DOAJ |
| description | Lan Liu,1 Meizuo Zhong,1,2 Xuan Zhou,3 Fanhua Kang,4 Yong Long,1 Junfeng Li1 1Department of Oncology, Xiangya Changde Hospital, Changde, Hunan, People’s Republic of China; 2Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 3Department of Hematology, Xiangya Changde hospital, Changde, Hunan, People’s Republic of China; 4Department of Pathology, Xiangya Changde Hospital, Changde, Hunan, People’s Republic of ChinaCorrespondence: Junfeng Li, Email 430723461x@163.comAbstract: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy. Most patients are diagnosed at a late stage with poor prognosis. The treatment usually includes combined intensive chemotherapy, cytoreductive surgery, radiotherapy, and targeted therapy. Due to the low incidence rate and dismal survival, there is currently a lack of case reports on DSRCT with concurrent leukemia. We report a case of a young patient who achieved disease stabilization for 14 months after receiving 6 cycles of chemotherapy and whole abdominal radiation therapy (WART), followed by consolidation treatment with anlotinib. However, the treatment was terminated due to the development of Acute Myeloid Leukemia-M5 (AML-M5). Multimodal therapy may provide a survival benefit for rare tumors that lack standard treatment. However, intensive chemotherapy and extensive radiotherapy carry a risk of inducing secondary malignancies. This is the first reported case of concurrent DSRCT and AML-M5 with short intervals between onset.Keywords: desmoplastic small round cell tumor, whole abdominal radiation therapy, anlotinib, therapy-related acute myeloid leukemia |
| first_indexed | 2024-03-07T16:24:26Z |
| format | Article |
| id | doaj.art-4962131b8c7246b4a72567c048a54ced |
| institution | Directory Open Access Journal |
| issn | 1178-6930 |
| language | English |
| last_indexed | 2024-03-07T16:24:26Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | OncoTargets and Therapy |
| spelling | doaj.art-4962131b8c7246b4a72567c048a54ced2024-03-03T18:36:48ZengDove Medical PressOncoTargets and Therapy1178-69302024-02-01Volume 1716316990751Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature ReviewLiu LZhong MZhou XKang FLong YLi JLan Liu,1 Meizuo Zhong,1,2 Xuan Zhou,3 Fanhua Kang,4 Yong Long,1 Junfeng Li1 1Department of Oncology, Xiangya Changde Hospital, Changde, Hunan, People’s Republic of China; 2Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 3Department of Hematology, Xiangya Changde hospital, Changde, Hunan, People’s Republic of China; 4Department of Pathology, Xiangya Changde Hospital, Changde, Hunan, People’s Republic of ChinaCorrespondence: Junfeng Li, Email 430723461x@163.comAbstract: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy. Most patients are diagnosed at a late stage with poor prognosis. The treatment usually includes combined intensive chemotherapy, cytoreductive surgery, radiotherapy, and targeted therapy. Due to the low incidence rate and dismal survival, there is currently a lack of case reports on DSRCT with concurrent leukemia. We report a case of a young patient who achieved disease stabilization for 14 months after receiving 6 cycles of chemotherapy and whole abdominal radiation therapy (WART), followed by consolidation treatment with anlotinib. However, the treatment was terminated due to the development of Acute Myeloid Leukemia-M5 (AML-M5). Multimodal therapy may provide a survival benefit for rare tumors that lack standard treatment. However, intensive chemotherapy and extensive radiotherapy carry a risk of inducing secondary malignancies. This is the first reported case of concurrent DSRCT and AML-M5 with short intervals between onset.Keywords: desmoplastic small round cell tumor, whole abdominal radiation therapy, anlotinib, therapy-related acute myeloid leukemiahttps://www.dovepress.com/treatment-of-abdominal-desmoplastic-small-round-cell-tumor-induces-acu-peer-reviewed-fulltext-article-OTTdesmoplastic small round cell tumorwhole abdominal radiation therapyanlotinibtherapy-related acute myeloid leukemia |
| spellingShingle | Liu L Zhong M Zhou X Kang F Long Y Li J Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review OncoTargets and Therapy desmoplastic small round cell tumor whole abdominal radiation therapy anlotinib therapy-related acute myeloid leukemia |
| title | Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review |
| title_full | Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review |
| title_fullStr | Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review |
| title_full_unstemmed | Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review |
| title_short | Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review |
| title_sort | treatment of abdominal desmoplastic small round cell tumor induces acute myeloid leukemia m5 a case report and literature review |
| topic | desmoplastic small round cell tumor whole abdominal radiation therapy anlotinib therapy-related acute myeloid leukemia |
| url | https://www.dovepress.com/treatment-of-abdominal-desmoplastic-small-round-cell-tumor-induces-acu-peer-reviewed-fulltext-article-OTT |
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