A review of bone marrow lesions in the arthritic knee and description of a technique for treatment
Introduction: Subchondral bone pathology includes a wide range of pathologies, such as osteoarthritis, spontaneous insufficiency fractures, osteonecrosis, transient bone marrow lesions syndromes, and trauma. They show typical magnetic resonance imaging (MRI) findings termed bone marrow lesions (BMLs...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Cartilage & Joint Preservation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254521000214 |
| _version_ | 1818690212318937088 |
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| author | Alberto Gobbi Ignacio Dallo Rachel M. Frank Hannah Bradsell Ivan Saenz William Murrel |
| author_facet | Alberto Gobbi Ignacio Dallo Rachel M. Frank Hannah Bradsell Ivan Saenz William Murrel |
| author_sort | Alberto Gobbi |
| collection | DOAJ |
| description | Introduction: Subchondral bone pathology includes a wide range of pathologies, such as osteoarthritis, spontaneous insufficiency fractures, osteonecrosis, transient bone marrow lesions syndromes, and trauma. They show typical magnetic resonance imaging (MRI) findings termed bone marrow lesions (BMLs). However, the etiology and evolution of BMLs in multiple conditions remains unclear. There is still no gold standard treatment protocol in treating BMLs in the knee, and a variety of treatment modalities have been tested in the hope that they might reduce pain and stop disease progression. Objectives: To review the treatment options for BMLs of the knee. Methods: A literature review was performed that included searches of PubMed, Cochrane, and Medline databases using the following keywords: Bone marrow lesions, sub chondroplasty, bone marrow concentrate, platelet-rich plasma (PRP), subchondral bone augmentation. Results: The use of novel biologic techniques to treat BMLs in the knee, such as PRP and Bone Marrow Cells, has yielded promising clinical outcomes. Conclusions: Future research of BMLs will be mandatory to address the different pathologies better and determining appropriate treatment strategies. There is still a need for high-quality RCTs studies and systematic reviews in the future to enhance further treatment strategy in preventing or treating BMLs of the knee. |
| first_indexed | 2024-12-17T12:22:24Z |
| format | Article |
| id | doaj.art-4964a8f172fa4f3cab8516a17d7c3529 |
| institution | Directory Open Access Journal |
| issn | 2667-2545 |
| language | English |
| last_indexed | 2024-12-17T12:22:24Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj.art-4964a8f172fa4f3cab8516a17d7c35292022-12-21T21:48:54ZengElsevierJournal of Cartilage & Joint Preservation2667-25452021-09-0113100021A review of bone marrow lesions in the arthritic knee and description of a technique for treatmentAlberto Gobbi0Ignacio Dallo1Rachel M. Frank2Hannah Bradsell3Ivan Saenz4William Murrel5O.A.S.I. Bioresearch Foundation, Gobbi Onlus, Milano, Italy; Corresponding author: Alberto Gobbi, O.A.S.I. Bioresearch Foundation, Gobbi Onlus, Milano, Italy.O.A.S.I. Bioresearch Foundation, Gobbi Onlus, Milano, ItalyUniversity of Colorado School of Medicine, Department of Orthopaedic surgery, Denver, CO, USAUniversity of Colorado School of Medicine, Department of Orthopaedic surgery, Denver, CO, USAFundacion Hospital Espíritu Santo, Santa Coloma de Gramanet, Barcelona, EspañaAbu Dhabi Knee and Sports Medicine, Healthpoint Hospital, Mubadala Healthcare, Abu Dhabi, UAE; 5-4 11th HC, Jacksonville, Florida, USAIntroduction: Subchondral bone pathology includes a wide range of pathologies, such as osteoarthritis, spontaneous insufficiency fractures, osteonecrosis, transient bone marrow lesions syndromes, and trauma. They show typical magnetic resonance imaging (MRI) findings termed bone marrow lesions (BMLs). However, the etiology and evolution of BMLs in multiple conditions remains unclear. There is still no gold standard treatment protocol in treating BMLs in the knee, and a variety of treatment modalities have been tested in the hope that they might reduce pain and stop disease progression. Objectives: To review the treatment options for BMLs of the knee. Methods: A literature review was performed that included searches of PubMed, Cochrane, and Medline databases using the following keywords: Bone marrow lesions, sub chondroplasty, bone marrow concentrate, platelet-rich plasma (PRP), subchondral bone augmentation. Results: The use of novel biologic techniques to treat BMLs in the knee, such as PRP and Bone Marrow Cells, has yielded promising clinical outcomes. Conclusions: Future research of BMLs will be mandatory to address the different pathologies better and determining appropriate treatment strategies. There is still a need for high-quality RCTs studies and systematic reviews in the future to enhance further treatment strategy in preventing or treating BMLs of the knee.http://www.sciencedirect.com/science/article/pii/S2667254521000214Bone Marrow LesionsBMAOsteo-Core-PlastyOsteochondral UnitKnee osteoarthritisSubchondral Bone Augmentation |
| spellingShingle | Alberto Gobbi Ignacio Dallo Rachel M. Frank Hannah Bradsell Ivan Saenz William Murrel A review of bone marrow lesions in the arthritic knee and description of a technique for treatment Journal of Cartilage & Joint Preservation Bone Marrow Lesions BMA Osteo-Core-Plasty Osteochondral Unit Knee osteoarthritis Subchondral Bone Augmentation |
| title | A review of bone marrow lesions in the arthritic knee and description of a technique for treatment |
| title_full | A review of bone marrow lesions in the arthritic knee and description of a technique for treatment |
| title_fullStr | A review of bone marrow lesions in the arthritic knee and description of a technique for treatment |
| title_full_unstemmed | A review of bone marrow lesions in the arthritic knee and description of a technique for treatment |
| title_short | A review of bone marrow lesions in the arthritic knee and description of a technique for treatment |
| title_sort | review of bone marrow lesions in the arthritic knee and description of a technique for treatment |
| topic | Bone Marrow Lesions BMA Osteo-Core-Plasty Osteochondral Unit Knee osteoarthritis Subchondral Bone Augmentation |
| url | http://www.sciencedirect.com/science/article/pii/S2667254521000214 |
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