Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis

Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis

In rodents, we identified a physiologic process within the normal liver that creates a pre-metastatic niche. This physiology is weaning-induced liver involution, characterized by hepatocyte cell death, immune influx, and extracellular matrix remodeling. Here, using weaning-induced liver involution a...

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Bibliographic Details
Main Authors: Alexandra Q. Bartlett, Nathan D. Pennock, Alex Klug, Pepper Schedin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
metastatic niche
liver metastasis
breast cancer
liver involution
Online Access:https://www.mdpi.com/2072-6694/13/7/1698

Internet

https://www.mdpi.com/2072-6694/13/7/1698

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