Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases
Epidemiological screening combined with serological tests has become an important tool at blood banks for the characterization of donors with or without Trypanosoma cruzi infection. Thus, the objective of the present study was to describe the sociodemographic and epidemiological characteristics of b...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2010-09-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600012 |
| _version_ | 1827879778353414144 |
|---|---|
| author | Márcia M Ferreira-Silva Gilberto A Pereira Eliane Lages-Silva Helio Moraes-Souza |
| author_facet | Márcia M Ferreira-Silva Gilberto A Pereira Eliane Lages-Silva Helio Moraes-Souza |
| author_sort | Márcia M Ferreira-Silva |
| collection | DOAJ |
| description | Epidemiological screening combined with serological tests has become an important tool at blood banks for the characterization of donors with or without Trypanosoma cruzi infection. Thus, the objective of the present study was to describe the sociodemographic and epidemiological characteristics of blood donors with non-negative serology for T. cruzito determine possible risk factors associated with serological ineligibility. Sociodemographic and epidemiological data were collected by analysis of patient histories and interviews. The data were analyzed descriptively using absolute and relative frequencies and odds ratio (OR) evaluation. The frequency of serological ineligibility was 0.28%, with a predominance of inconclusive reactions (52%) and seropositivity among first-time donors (OR = 607), donors older than 30 years (OR = 3.7), females (OR = 1.9), donors from risk areas (OR = 4) and subjects living in rural areas (OR = 1.7). The risk of seropositivity was higher among donors who had contact with the triatomine vector (OR = 11.7) and those with a family history of Chagas disease (OR = 4.8). The results demonstrate the value of detailed clinical-epidemiological screening as an auxiliary tool for serological definition that, together with more specific and more sensitive laboratory methods, will guarantee a higher efficacy in the selection of donors at blood centres. |
| first_indexed | 2024-03-12T18:11:14Z |
| format | Article |
| id | doaj.art-49686caffc2b4196abcf82352e6f9ae9 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:11:14Z |
| publishDate | 2010-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-49686caffc2b4196abcf82352e6f9ae92023-08-02T09:15:30ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-09-01105680080510.1590/S0074-02762010000600012Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive casesMárcia M Ferreira-SilvaGilberto A PereiraEliane Lages-SilvaHelio Moraes-SouzaEpidemiological screening combined with serological tests has become an important tool at blood banks for the characterization of donors with or without Trypanosoma cruzi infection. Thus, the objective of the present study was to describe the sociodemographic and epidemiological characteristics of blood donors with non-negative serology for T. cruzito determine possible risk factors associated with serological ineligibility. Sociodemographic and epidemiological data were collected by analysis of patient histories and interviews. The data were analyzed descriptively using absolute and relative frequencies and odds ratio (OR) evaluation. The frequency of serological ineligibility was 0.28%, with a predominance of inconclusive reactions (52%) and seropositivity among first-time donors (OR = 607), donors older than 30 years (OR = 3.7), females (OR = 1.9), donors from risk areas (OR = 4) and subjects living in rural areas (OR = 1.7). The risk of seropositivity was higher among donors who had contact with the triatomine vector (OR = 11.7) and those with a family history of Chagas disease (OR = 4.8). The results demonstrate the value of detailed clinical-epidemiological screening as an auxiliary tool for serological definition that, together with more specific and more sensitive laboratory methods, will guarantee a higher efficacy in the selection of donors at blood centres.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600012blood donorsChagas diseaseserological ineligibilityinconclusive serologysocioepidemiological screening |
| spellingShingle | Márcia M Ferreira-Silva Gilberto A Pereira Eliane Lages-Silva Helio Moraes-Souza Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases Memorias do Instituto Oswaldo Cruz blood donors Chagas disease serological ineligibility inconclusive serology socioepidemiological screening |
| title | Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases |
| title_full | Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases |
| title_fullStr | Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases |
| title_full_unstemmed | Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases |
| title_short | Socioepidemiological screening of serologically ineligible blood donors due to Chagas disease for the definition of inconclusive cases |
| title_sort | socioepidemiological screening of serologically ineligible blood donors due to chagas disease for the definition of inconclusive cases |
| topic | blood donors Chagas disease serological ineligibility inconclusive serology socioepidemiological screening |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600012 |
| work_keys_str_mv | AT marciamferreirasilva socioepidemiologicalscreeningofserologicallyineligibleblooddonorsduetochagasdiseaseforthedefinitionofinconclusivecases AT gilbertoapereira socioepidemiologicalscreeningofserologicallyineligibleblooddonorsduetochagasdiseaseforthedefinitionofinconclusivecases AT elianelagessilva socioepidemiologicalscreeningofserologicallyineligibleblooddonorsduetochagasdiseaseforthedefinitionofinconclusivecases AT heliomoraessouza socioepidemiologicalscreeningofserologicallyineligibleblooddonorsduetochagasdiseaseforthedefinitionofinconclusivecases |