Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer
Gastric cancer (GC) is one of the most common malignancies worldwide and the leading cause of cancer-related deaths. Exosomes are nanoscale extracellular vesicles secreted by a variety of cells and play an important role in cellular communication and epigenetics by transporting bioactive substances...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1236679/full |
| _version_ | 1797448258535030784 |
|---|---|
| author | Ming Han Mengyuan Zhang Mei Qi Yue Zhou Fulong Li Shengquan Fang |
| author_facet | Ming Han Mengyuan Zhang Mei Qi Yue Zhou Fulong Li Shengquan Fang |
| author_sort | Ming Han |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most common malignancies worldwide and the leading cause of cancer-related deaths. Exosomes are nanoscale extracellular vesicles secreted by a variety of cells and play an important role in cellular communication and epigenetics by transporting bioactive substances in the tumor microenvironment (TME). Circular RNA (circRNA) is a type of non-coding RNA (ncRNA) with a specific structure, which is widely enriched in exosomes and is involved in various pathophysiological processes mediated by exosomes. Exosomal circRNAs play a critical role in the development of GC by regulating epithelial-mesenchymal transition (EMT), angiogenesis, proliferation, invasion, migration, and metastasis of GC. Given the biological characteristics of exosomal circRNAs, they have more significant diagnostic sensitivity and specificity in the clinic and may become biomarkers for GC diagnosis and prognosis. In this review, we briefly describe the biogenesis of exosomes and circRNAs and their biological functions, comprehensively summarize the mechanisms of exosomal circRNAs in the development of GC and chemotherapy resistance, and finally, we discuss the potential clinical application value and challenges of exosomal circRNAs in GC. |
| first_indexed | 2024-03-09T14:07:45Z |
| format | Article |
| id | doaj.art-496e30e792224f37b9c08562454509b1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-09T14:07:45Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-496e30e792224f37b9c08562454509b12023-11-29T21:15:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-11-011310.3389/fonc.2023.12366791236679Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancerMing HanMengyuan ZhangMei QiYue ZhouFulong LiShengquan FangGastric cancer (GC) is one of the most common malignancies worldwide and the leading cause of cancer-related deaths. Exosomes are nanoscale extracellular vesicles secreted by a variety of cells and play an important role in cellular communication and epigenetics by transporting bioactive substances in the tumor microenvironment (TME). Circular RNA (circRNA) is a type of non-coding RNA (ncRNA) with a specific structure, which is widely enriched in exosomes and is involved in various pathophysiological processes mediated by exosomes. Exosomal circRNAs play a critical role in the development of GC by regulating epithelial-mesenchymal transition (EMT), angiogenesis, proliferation, invasion, migration, and metastasis of GC. Given the biological characteristics of exosomal circRNAs, they have more significant diagnostic sensitivity and specificity in the clinic and may become biomarkers for GC diagnosis and prognosis. In this review, we briefly describe the biogenesis of exosomes and circRNAs and their biological functions, comprehensively summarize the mechanisms of exosomal circRNAs in the development of GC and chemotherapy resistance, and finally, we discuss the potential clinical application value and challenges of exosomal circRNAs in GC.https://www.frontiersin.org/articles/10.3389/fonc.2023.1236679/fullgastric cancerexosomal circRNAsepithelial-mesenchymal transitionchemotherapy resistancebiomarkers |
| spellingShingle | Ming Han Mengyuan Zhang Mei Qi Yue Zhou Fulong Li Shengquan Fang Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer Frontiers in Oncology gastric cancer exosomal circRNAs epithelial-mesenchymal transition chemotherapy resistance biomarkers |
| title | Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer |
| title_full | Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer |
| title_fullStr | Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer |
| title_full_unstemmed | Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer |
| title_short | Regulatory mechanism and promising clinical application of exosomal circular RNA in gastric cancer |
| title_sort | regulatory mechanism and promising clinical application of exosomal circular rna in gastric cancer |
| topic | gastric cancer exosomal circRNAs epithelial-mesenchymal transition chemotherapy resistance biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1236679/full |
| work_keys_str_mv | AT minghan regulatorymechanismandpromisingclinicalapplicationofexosomalcircularrnaingastriccancer AT mengyuanzhang regulatorymechanismandpromisingclinicalapplicationofexosomalcircularrnaingastriccancer AT meiqi regulatorymechanismandpromisingclinicalapplicationofexosomalcircularrnaingastriccancer AT yuezhou regulatorymechanismandpromisingclinicalapplicationofexosomalcircularrnaingastriccancer AT fulongli regulatorymechanismandpromisingclinicalapplicationofexosomalcircularrnaingastriccancer AT shengquanfang regulatorymechanismandpromisingclinicalapplicationofexosomalcircularrnaingastriccancer |