Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis
Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1124330/full |
| _version_ | 1797744325791055872 |
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| author | Shi-Yi Lyu Wang Xiao Guang-Zu Cui Cheng Yu Huan Liu Min Lyu Qian-Ya Kuang En-Hua Xiao Yong-Heng Luo |
| author_facet | Shi-Yi Lyu Wang Xiao Guang-Zu Cui Cheng Yu Huan Liu Min Lyu Qian-Ya Kuang En-Hua Xiao Yong-Heng Luo |
| author_sort | Shi-Yi Lyu |
| collection | DOAJ |
| description | Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has not yet been elucidated. The molecular basis of HSC activation involves changes in the regulation of gene expression without changes in the genome sequence, namely, via epigenetic regulation. DNA methylation is a key focus of epigenetic research, as it affects the expression of fibrosis-related, metabolism-related, and tumor suppressor genes. Increasing studies have shown that DNA methylation is closely related to several physiological and pathological processes including HSC activation and liver fibrosis. This review aimed to discuss the mechanism of DNA methylation in the pathogenesis of liver fibrosis, explore DNA methylation inhibitors as potential therapies for liver fibrosis, and provide new insights on the prevention and clinical treatment of liver fibrosis. |
| first_indexed | 2024-03-12T15:08:07Z |
| format | Article |
| id | doaj.art-496e76c4ea5b4fc38d494ec692cd2508 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-12T15:08:07Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj.art-496e76c4ea5b4fc38d494ec692cd25082023-08-12T00:46:19ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-03-011410.3389/fgene.2023.11243301124330Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosisShi-Yi Lyu0Wang Xiao1Guang-Zu Cui2Cheng Yu3Huan Liu4Min Lyu5Qian-Ya Kuang6En-Hua Xiao7Yong-Heng Luo8Department of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaDepartment of Gastrointestinal Surgery, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaXiangYa School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital, Central-South University, Changsha, Hunan, ChinaLiver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has not yet been elucidated. The molecular basis of HSC activation involves changes in the regulation of gene expression without changes in the genome sequence, namely, via epigenetic regulation. DNA methylation is a key focus of epigenetic research, as it affects the expression of fibrosis-related, metabolism-related, and tumor suppressor genes. Increasing studies have shown that DNA methylation is closely related to several physiological and pathological processes including HSC activation and liver fibrosis. This review aimed to discuss the mechanism of DNA methylation in the pathogenesis of liver fibrosis, explore DNA methylation inhibitors as potential therapies for liver fibrosis, and provide new insights on the prevention and clinical treatment of liver fibrosis.https://www.frontiersin.org/articles/10.3389/fgene.2023.1124330/fullhepatic fibrosisDNA methylationepigeneticshepatic stellate cells (HSCs)DNA methylation inhibitors |
| spellingShingle | Shi-Yi Lyu Wang Xiao Guang-Zu Cui Cheng Yu Huan Liu Min Lyu Qian-Ya Kuang En-Hua Xiao Yong-Heng Luo Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis Frontiers in Genetics hepatic fibrosis DNA methylation epigenetics hepatic stellate cells (HSCs) DNA methylation inhibitors |
| title | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
| title_full | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
| title_fullStr | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
| title_full_unstemmed | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
| title_short | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
| title_sort | role and mechanism of dna methylation and its inhibitors in hepatic fibrosis |
| topic | hepatic fibrosis DNA methylation epigenetics hepatic stellate cells (HSCs) DNA methylation inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1124330/full |
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