Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma
This study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in a highly simultaneous manner through the application of a safe, non-toxic, locally sustained drug-releasing composite Nanofiber m...
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MDPI AG
2023-01-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/3/414 |
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| author | Yinuo Li Yoshitaka Matsumoto Lili Chen Yu Sugawara Emiho Oe Nanami Fujisawa Mitsuhiro Ebara Hideyuki Sakurai |
| author_facet | Yinuo Li Yoshitaka Matsumoto Lili Chen Yu Sugawara Emiho Oe Nanami Fujisawa Mitsuhiro Ebara Hideyuki Sakurai |
| author_sort | Yinuo Li |
| collection | DOAJ |
| description | This study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in a highly simultaneous manner through the application of a safe, non-toxic, locally sustained drug-releasing composite Nanofiber mesh (NFM). The NFM consisted of biodegradable poly(ε-caprolactone) with temozolomide (TMZ) and 17-allylamino-17-demethoxygeldanamycin (17AAG), which was used in radiation treatment. TMZ and 17AAG combination showed a synergistic cytotoxicity effect in the T98G cell model. TMZ and 17AAG induced a radiation-sensitization effect, respectively. The NFM containing 17AAG or TMZ, known as 17AAG-NFM and TMZ-NFM, enabled cumulative drug release of 34.1% and 39.7% within 35 days. Moreover, 17AAG+TMZ-NFM containing both drugs revealed a synergistic effect in relation to the NFM of a single agent. When combined with radiation, 17AAG+TMZ-NFM induced in an extremely powerful cytotoxic effect. These results confirmed the application of NFM can simultaneously allow multiple treatments to T98G cells. Each modality achieved a significant synergistic effect with the other, leading to a cascading amplification of the therapeutic effect. Due to the superior advantage of sustained drug release over a long period of time, NFM has the promise of clinically addressing the challenge of high recurrence of GBM post-operatively. |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T09:32:15Z |
| publishDate | 2023-01-01 |
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| series | Nanomaterials |
| spelling | doaj.art-496fdefa13ba4339a4c9f3df0b24fdeb2023-11-16T17:34:19ZengMDPI AGNanomaterials2079-49912023-01-0113341410.3390/nano13030414Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for GlioblastomaYinuo Li0Yoshitaka Matsumoto1Lili Chen2Yu Sugawara3Emiho Oe4Nanami Fujisawa5Mitsuhiro Ebara6Hideyuki Sakurai7Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, JapanDepartment of Radiation Oncology, Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, JapanResearch Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, JapanProton Medical Research Center, University of Tsukuba Hospital, Tsukuba 305-8576, JapanResearch Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, JapanResearch Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, JapanResearch Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, JapanDepartment of Radiation Oncology, Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, JapanThis study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in a highly simultaneous manner through the application of a safe, non-toxic, locally sustained drug-releasing composite Nanofiber mesh (NFM). The NFM consisted of biodegradable poly(ε-caprolactone) with temozolomide (TMZ) and 17-allylamino-17-demethoxygeldanamycin (17AAG), which was used in radiation treatment. TMZ and 17AAG combination showed a synergistic cytotoxicity effect in the T98G cell model. TMZ and 17AAG induced a radiation-sensitization effect, respectively. The NFM containing 17AAG or TMZ, known as 17AAG-NFM and TMZ-NFM, enabled cumulative drug release of 34.1% and 39.7% within 35 days. Moreover, 17AAG+TMZ-NFM containing both drugs revealed a synergistic effect in relation to the NFM of a single agent. When combined with radiation, 17AAG+TMZ-NFM induced in an extremely powerful cytotoxic effect. These results confirmed the application of NFM can simultaneously allow multiple treatments to T98G cells. Each modality achieved a significant synergistic effect with the other, leading to a cascading amplification of the therapeutic effect. Due to the superior advantage of sustained drug release over a long period of time, NFM has the promise of clinically addressing the challenge of high recurrence of GBM post-operatively.https://www.mdpi.com/2079-4991/13/3/414glioblastomacombination therapysynergistic effectTMZ17AAGradiation therapy |
| spellingShingle | Yinuo Li Yoshitaka Matsumoto Lili Chen Yu Sugawara Emiho Oe Nanami Fujisawa Mitsuhiro Ebara Hideyuki Sakurai Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma Nanomaterials glioblastoma combination therapy synergistic effect TMZ 17AAG radiation therapy |
| title | Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma |
| title_full | Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma |
| title_fullStr | Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma |
| title_full_unstemmed | Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma |
| title_short | Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma |
| title_sort | smart nanofiber mesh with locally sustained drug release enabled synergistic combination therapy for glioblastoma |
| topic | glioblastoma combination therapy synergistic effect TMZ 17AAG radiation therapy |
| url | https://www.mdpi.com/2079-4991/13/3/414 |
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