The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer

Abstract Objective Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate...

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Main Authors: Melissa Gonzalez Veiga, Rogério Tadeu Felizi, Dayane Guerino Reis, Ivo Carelli Filho, Cesar Eduardo Fernandes, Ricardo Peres do Souto, Emerson Oliveira
Format: Article
Language:English
Published: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia 2018-11-01
Series:Revista Brasileira de Ginecologia e Obstetrícia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001100699&tlng=en
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author Melissa Gonzalez Veiga
Rogério Tadeu Felizi
Dayane Guerino Reis
Ivo Carelli Filho
Cesar Eduardo Fernandes
Ricardo Peres do Souto
Emerson Oliveira
author_facet Melissa Gonzalez Veiga
Rogério Tadeu Felizi
Dayane Guerino Reis
Ivo Carelli Filho
Cesar Eduardo Fernandes
Ricardo Peres do Souto
Emerson Oliveira
author_sort Melissa Gonzalez Veiga
collection DOAJ
description Abstract Objective Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the CYP3A4*1B gene polymorphism (rs2740574) and the risk of developing breast cancer. Methods In the present case-control study, the frequency of the CYP3A4*1B gene polymorphism was determined in 148 women with breast cancer and in 245 women without the disease. The DNA of the participants was extracted from plasma samples, and the gene was amplified by polymerase chain reaction. The presence of the polymorphism was determined using restriction enzymes. Results After adjusting for confounding variables, we have found that the polymorphism was not associated with the occurrence of breast cancer (odds ratio = 1.151; 95% confidence interval: 0.714–1.856; p= 0.564). We have also found no association with the presence of hormone receptors, with human epidermal growth factor receptor 2 (HER2) overexpression, or with the rate of tumor cell proliferation. Conclusion We have not observed a relationship between the CYP3A4*1B gene polymorphism and the occurrence of breast cancer.
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spelling doaj.art-4971228c4409496dba8468b04970385d2022-12-22T04:13:09ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032018-11-01401169970410.1055/s-0038-1673365The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast CancerMelissa Gonzalez VeigaRogério Tadeu FeliziDayane Guerino ReisIvo Carelli FilhoCesar Eduardo FernandesRicardo Peres do SoutoEmerson OliveiraAbstract Objective Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the CYP3A4*1B gene polymorphism (rs2740574) and the risk of developing breast cancer. Methods In the present case-control study, the frequency of the CYP3A4*1B gene polymorphism was determined in 148 women with breast cancer and in 245 women without the disease. The DNA of the participants was extracted from plasma samples, and the gene was amplified by polymerase chain reaction. The presence of the polymorphism was determined using restriction enzymes. Results After adjusting for confounding variables, we have found that the polymorphism was not associated with the occurrence of breast cancer (odds ratio = 1.151; 95% confidence interval: 0.714–1.856; p= 0.564). We have also found no association with the presence of hormone receptors, with human epidermal growth factor receptor 2 (HER2) overexpression, or with the rate of tumor cell proliferation. Conclusion We have not observed a relationship between the CYP3A4*1B gene polymorphism and the occurrence of breast cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001100699&tlng=enCyp3a4breast cancerpolymorphismestrogensgenetics
spellingShingle Melissa Gonzalez Veiga
Rogério Tadeu Felizi
Dayane Guerino Reis
Ivo Carelli Filho
Cesar Eduardo Fernandes
Ricardo Peres do Souto
Emerson Oliveira
The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer
Revista Brasileira de Ginecologia e Obstetrícia
Cyp3a4
breast cancer
polymorphism
estrogens
genetics
title The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer
title_full The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer
title_fullStr The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer
title_full_unstemmed The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer
title_short The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer
title_sort influence of cyp3a4 polymorphism in sex steroids as a risk factor for breast cancer
topic Cyp3a4
breast cancer
polymorphism
estrogens
genetics
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001100699&tlng=en
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