Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study
Background: Despite growing interest in cutaneous adverse events (CAEs) and their management in patients with cancer, they are often underreported and there are no extensive data on their impact on quality of life (QoL). Healthcare professionals should consider this issue in order to minimize its ne...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BioExcel Publishing Ltd
2020-08-01
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| Series: | Drugs in Context |
| Subjects: | |
| Online Access: | https://www.drugsincontext.com/cutaneous-adverse-events-and-quality-of-life-in-outpatients-receiving-anticancer-agents:-results-from-an-observational,-cross-sectional-study |
| _version_ | 1818519469168787456 |
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| author | Hae-Jin Suh Oh Ángeles Flórez Menéndez Víctor Sacristán Santos Francisca Fernández Ribeiro Lucía Vilanova-Trillo Manuel Constenla Figueiras Manuel Pereiro Ferreiros |
| author_facet | Hae-Jin Suh Oh Ángeles Flórez Menéndez Víctor Sacristán Santos Francisca Fernández Ribeiro Lucía Vilanova-Trillo Manuel Constenla Figueiras Manuel Pereiro Ferreiros |
| author_sort | Hae-Jin Suh Oh |
| collection | DOAJ |
| description | Background: Despite growing interest in cutaneous adverse events (CAEs) and their management in patients with cancer, they are often underreported and there are no extensive data on their impact on quality of life (QoL). Healthcare professionals should consider this issue in order to minimize its negative impact on QoL and improve patient outcomes. This study evaluates the impact of CAEs on QoL in outpatients receiving anticancer drugs and aims to determine the differences in QoL between conventional chemotherapy versus targeted therapies.
Methods: A total of 114 cancer patients with CAEs were included in this observational, cross-sectional study. Patient-reported outcomes instruments (Functional Assessment of Cancer Therapy – General, Dermatology Life Quality Index, and Skindex-16) were used.
Results: Mean scores in QoL indices were 65.3±13.4, 8.4±5, and 30.8±16.9 in Functional Assessment of Cancer Therapy – General, Dermatology Life Quality Index, and Skindex-16, respectively. The CAEs that had the greatest impact on dermatologic-related QoL were hand–foot skin reaction, rash, palmo-plantar erythrodysesthesia, and papulopustular eruption. No significant differences in QoL indices according to the type of treatment (conventional chemotherapy versus targeted therapy) were observed.
Conclusions: CAEs, and particularly hand–foot toxicities, rashes, and papulopustular eruptions, can have an impact on QoL in outpatients receiving anticancer drugs as evaluated with three different patient-reported outcomes instruments. No differences in QoL related to CAEs were observed between conventional chemotherapy and targeted therapy. |
| first_indexed | 2024-12-11T01:24:37Z |
| format | Article |
| id | doaj.art-49721c07f52942ee8c6fcc478299ebdb |
| institution | Directory Open Access Journal |
| issn | 1740-4398 1740-4398 |
| language | English |
| last_indexed | 2024-12-11T01:24:37Z |
| publishDate | 2020-08-01 |
| publisher | BioExcel Publishing Ltd |
| record_format | Article |
| series | Drugs in Context |
| spelling | doaj.art-49721c07f52942ee8c6fcc478299ebdb2022-12-22T01:25:35ZengBioExcel Publishing LtdDrugs in Context1740-43981740-43982020-08-01911010.7573/dic.2020-6-6Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional studyHae-Jin Suh OhÁngeles Flórez MenéndezVíctor Sacristán SantosFrancisca Fernández RibeiroLucía Vilanova-TrilloManuel Constenla FigueirasManuel Pereiro FerreirosBackground: Despite growing interest in cutaneous adverse events (CAEs) and their management in patients with cancer, they are often underreported and there are no extensive data on their impact on quality of life (QoL). Healthcare professionals should consider this issue in order to minimize its negative impact on QoL and improve patient outcomes. This study evaluates the impact of CAEs on QoL in outpatients receiving anticancer drugs and aims to determine the differences in QoL between conventional chemotherapy versus targeted therapies. Methods: A total of 114 cancer patients with CAEs were included in this observational, cross-sectional study. Patient-reported outcomes instruments (Functional Assessment of Cancer Therapy – General, Dermatology Life Quality Index, and Skindex-16) were used. Results: Mean scores in QoL indices were 65.3±13.4, 8.4±5, and 30.8±16.9 in Functional Assessment of Cancer Therapy – General, Dermatology Life Quality Index, and Skindex-16, respectively. The CAEs that had the greatest impact on dermatologic-related QoL were hand–foot skin reaction, rash, palmo-plantar erythrodysesthesia, and papulopustular eruption. No significant differences in QoL indices according to the type of treatment (conventional chemotherapy versus targeted therapy) were observed. Conclusions: CAEs, and particularly hand–foot toxicities, rashes, and papulopustular eruptions, can have an impact on QoL in outpatients receiving anticancer drugs as evaluated with three different patient-reported outcomes instruments. No differences in QoL related to CAEs were observed between conventional chemotherapy and targeted therapy.https://www.drugsincontext.com/cutaneous-adverse-events-and-quality-of-life-in-outpatients-receiving-anticancer-agents:-results-from-an-observational,-cross-sectional-studycutaneous adverse eventspatient-reported outcomesquality of lifetargeted therapies |
| spellingShingle | Hae-Jin Suh Oh Ángeles Flórez Menéndez Víctor Sacristán Santos Francisca Fernández Ribeiro Lucía Vilanova-Trillo Manuel Constenla Figueiras Manuel Pereiro Ferreiros Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study Drugs in Context cutaneous adverse events patient-reported outcomes quality of life targeted therapies |
| title | Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study |
| title_full | Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study |
| title_fullStr | Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study |
| title_full_unstemmed | Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study |
| title_short | Cutaneous adverse events and quality of life in outpatients receiving anticancer agents: results from an observational, cross-sectional study |
| title_sort | cutaneous adverse events and quality of life in outpatients receiving anticancer agents results from an observational cross sectional study |
| topic | cutaneous adverse events patient-reported outcomes quality of life targeted therapies |
| url | https://www.drugsincontext.com/cutaneous-adverse-events-and-quality-of-life-in-outpatients-receiving-anticancer-agents:-results-from-an-observational,-cross-sectional-study |
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