Spinal central effects of peripherally applied botulinum neurotoxin A in comparison between its subtypes A1 and A2

Spinal central effects of peripherally applied botulinum neurotoxin A in comparison between its subtypes A1 and A2

Because of its unique ability to exert long-lasting synaptic transmission blockade, botulinum neurotoxin A (BoNT/A) is used to treat a wide variety of disorders involving peripheral nerve terminal hyperexcitability. However, it has been a matter of debate whether this toxin has central or peripheral...

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Bibliographic Details
Main Authors: Hidetaka eKoizumi, Satoshi eGoto, Shinya eOkita, Ryoma eMorigaki, Norio eAkaike, Yasushi eTorii, Tetsuhiro eHarakawa, Akihiro eGinnaga, Ryuji eKaji
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Neurology
Subjects:
Spinal Cord
Botulinum Neurotoxin
Central effects
SNAP-25
Axonal transport.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00098/full

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