RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis
RF amide-related peptide 3 (RFRP-3) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis. In this study, we evaluated the effect of acute or chronic RFRP-3 treatment (administered via intraperitoneal injection) on the food intake, meal micr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00194/full |
| _version_ | 1818575248721707008 |
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| author | Konglin Huo Xun Li Wen Hu Xingxing Song Duoni Zhang Xin Zhang Xinyi Chen Jingzhi Yuan Jianyu Zuo Xiaoye Wang |
| author_facet | Konglin Huo Xun Li Wen Hu Xingxing Song Duoni Zhang Xin Zhang Xinyi Chen Jingzhi Yuan Jianyu Zuo Xiaoye Wang |
| author_sort | Konglin Huo |
| collection | DOAJ |
| description | RF amide-related peptide 3 (RFRP-3) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis. In this study, we evaluated the effect of acute or chronic RFRP-3 treatment (administered via intraperitoneal injection) on the food intake, meal microstructure and weight of rats, as well as the mechanism through which RFRP-3 is involved in glucose metabolism in the pancreas and glucose disposal tissues of rat in vivo. Our results showed that the intraperitoneal administration of RFRP-3 to rats resulted in marked body mass increased, hyperphagia, hyperlipidemia, hyperglycemia, glucose intolerance, hypoinsulinism, hyperglucagon, and insulin resistance, as well as significant increases in the size of pancreatic islets and the inflammatory reaction. Thus, we strongly assert that RFRP-3 as a novel neuroendocrine regulator involved in blood glucose homeostasis. |
| first_indexed | 2024-12-15T00:37:40Z |
| format | Article |
| id | doaj.art-497427065d0d420ba61ff11a62d4a706 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-15T00:37:40Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-497427065d0d420ba61ff11a62d4a7062022-12-21T22:41:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-04-011110.3389/fendo.2020.00194506807RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose HomeostasisKonglin HuoXun LiWen HuXingxing SongDuoni ZhangXin ZhangXinyi ChenJingzhi YuanJianyu ZuoXiaoye WangRF amide-related peptide 3 (RFRP-3) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis. In this study, we evaluated the effect of acute or chronic RFRP-3 treatment (administered via intraperitoneal injection) on the food intake, meal microstructure and weight of rats, as well as the mechanism through which RFRP-3 is involved in glucose metabolism in the pancreas and glucose disposal tissues of rat in vivo. Our results showed that the intraperitoneal administration of RFRP-3 to rats resulted in marked body mass increased, hyperphagia, hyperlipidemia, hyperglycemia, glucose intolerance, hypoinsulinism, hyperglucagon, and insulin resistance, as well as significant increases in the size of pancreatic islets and the inflammatory reaction. Thus, we strongly assert that RFRP-3 as a novel neuroendocrine regulator involved in blood glucose homeostasis.https://www.frontiersin.org/article/10.3389/fendo.2020.00194/fullRFamide-related peptide-3 (RFRP-3)food intakeinsulinglucagoninsulin resistanceglucose metabolism |
| spellingShingle | Konglin Huo Xun Li Wen Hu Xingxing Song Duoni Zhang Xin Zhang Xinyi Chen Jingzhi Yuan Jianyu Zuo Xiaoye Wang RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis Frontiers in Endocrinology RFamide-related peptide-3 (RFRP-3) food intake insulin glucagon insulin resistance glucose metabolism |
| title | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis |
| title_full | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis |
| title_fullStr | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis |
| title_full_unstemmed | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis |
| title_short | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis |
| title_sort | rfrp 3 the mammalian ortholog of gnih is a novel modulator involved in food intake and glucose homeostasis |
| topic | RFamide-related peptide-3 (RFRP-3) food intake insulin glucagon insulin resistance glucose metabolism |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00194/full |
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