Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.

Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.

Methylated arginines are endogenous analogues of L-arginine, the substrate for nitric oxide (NO) synthase. Asymmetric dimethylarginine (ADMA) interferes with NO formation, causing endothelial dysfunction. ADMA is a predictor of cardiovascular events and mortality in humans. It is eliminated primaril...

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Bibliographic Details
Main Authors:	Frank Leypoldt, Chi-Un Choe, Mathias Gelderblom, Eike-Christin von Leitner, Dorothee Atzler, Edzard Schwedhelm, Christian Gerloff, Karsten Sydow, Rainer H Böger, Tim Magnus
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-10-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2753663?pdf=render

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