Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
There is a lack of research on women with infertility in the northern latitudes, where vitamin D insufficiency is high. Therefore, this study aimed to assess the prevalence and determinants of vitamin D insufficiency (serum 25(OH)D concentration < 50 nmol/L) among women undergoing in vitro fertil...
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MDPI AG
2023-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/12/2820 |
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| author | Paulina Maaherra Armstrong Hanna Augustin Linnea Bärebring Amra Osmancevic Maria Bullarbo Ann Thurin-Kjellberg Panagiotis Tsiartas |
| author_facet | Paulina Maaherra Armstrong Hanna Augustin Linnea Bärebring Amra Osmancevic Maria Bullarbo Ann Thurin-Kjellberg Panagiotis Tsiartas |
| author_sort | Paulina Maaherra Armstrong |
| collection | DOAJ |
| description | There is a lack of research on women with infertility in the northern latitudes, where vitamin D insufficiency is high. Therefore, this study aimed to assess the prevalence and determinants of vitamin D insufficiency (serum 25(OH)D concentration < 50 nmol/L) among women undergoing in vitro fertilization (IVF) treatment. Thus, 265 women scheduled for IVF/intracytoplasmic sperm injection (ICSI) between September 2020 and August 2021 at Sahlgrenska University Hospital in Gothenburg, Sweden, were included. Data on serum 25(OH)D concentration, vitamin D intake, and sun exposure were collected via questionnaires and blood samples. Approximately 27% of the women had 25(OH)D insufficiency, which was associated with longer infertility duration. The likelihood of insufficiency was higher among women from non-Nordic European countries (OR 2.92, 95% CI 1.03–8.26, adjusted <i>p</i> = 0.043), the Middle East (OR 9.90, 95% CI 3.32–29.41, adjusted <i>p</i> < 0.001), and Asia (OR 5.49, 95% CI 1.30–23.25, adjusted <i>p</i> = 0.020) than among women from Nordic countries. Women who did not use vitamin D supplements were more likely to have insufficiency compared with supplement users (OR 3.32, 95% CI 1.55–7.10, adjusted <i>p</i> = 0.002), and those who avoided sun exposure had higher odds of insufficiency compared to those who stayed “in the sun all the time” (OR 3.24, 95% CI 1.22–8.62, adjusted <i>p</i> = 0.018). Women with infertility in northern latitudes and those from non-Nordic countries who avoid sun exposure and do not take vitamin supplements have a higher prevalence of 25(OH)D insufficiency and longer infertility duration. |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T02:04:05Z |
| publishDate | 2023-06-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-49744b167bf94618a264fa95dddb8a002023-11-18T11:58:03ZengMDPI AGNutrients2072-66432023-06-011512282010.3390/nu15122820Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in SwedenPaulina Maaherra Armstrong0Hanna Augustin1Linnea Bärebring2Amra Osmancevic3Maria Bullarbo4Ann Thurin-Kjellberg5Panagiotis Tsiartas6Department of Obstetrics and Gynecology, Reproductive Medicine, Sahlgrenska University Hospital, 413 45 Gothenburg, SwedenDepartment of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Obstetrics and Gynecology, Reproductive Medicine, Sahlgrenska University Hospital, 413 45 Gothenburg, SwedenNordic IVF Solna, Eugin Group, 171 54 Solna, SwedenThere is a lack of research on women with infertility in the northern latitudes, where vitamin D insufficiency is high. Therefore, this study aimed to assess the prevalence and determinants of vitamin D insufficiency (serum 25(OH)D concentration < 50 nmol/L) among women undergoing in vitro fertilization (IVF) treatment. Thus, 265 women scheduled for IVF/intracytoplasmic sperm injection (ICSI) between September 2020 and August 2021 at Sahlgrenska University Hospital in Gothenburg, Sweden, were included. Data on serum 25(OH)D concentration, vitamin D intake, and sun exposure were collected via questionnaires and blood samples. Approximately 27% of the women had 25(OH)D insufficiency, which was associated with longer infertility duration. The likelihood of insufficiency was higher among women from non-Nordic European countries (OR 2.92, 95% CI 1.03–8.26, adjusted <i>p</i> = 0.043), the Middle East (OR 9.90, 95% CI 3.32–29.41, adjusted <i>p</i> < 0.001), and Asia (OR 5.49, 95% CI 1.30–23.25, adjusted <i>p</i> = 0.020) than among women from Nordic countries. Women who did not use vitamin D supplements were more likely to have insufficiency compared with supplement users (OR 3.32, 95% CI 1.55–7.10, adjusted <i>p</i> = 0.002), and those who avoided sun exposure had higher odds of insufficiency compared to those who stayed “in the sun all the time” (OR 3.24, 95% CI 1.22–8.62, adjusted <i>p</i> = 0.018). Women with infertility in northern latitudes and those from non-Nordic countries who avoid sun exposure and do not take vitamin supplements have a higher prevalence of 25(OH)D insufficiency and longer infertility duration.https://www.mdpi.com/2072-6643/15/12/2820vitamin D insufficiency25-hydroxyvitamin Dinfertilityin vitro fertilizationdietary assessmentsun exposure |
| spellingShingle | Paulina Maaherra Armstrong Hanna Augustin Linnea Bärebring Amra Osmancevic Maria Bullarbo Ann Thurin-Kjellberg Panagiotis Tsiartas Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden Nutrients vitamin D insufficiency 25-hydroxyvitamin D infertility in vitro fertilization dietary assessment sun exposure |
| title | Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden |
| title_full | Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden |
| title_fullStr | Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden |
| title_full_unstemmed | Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden |
| title_short | Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden |
| title_sort | prevalence of vitamin d insufficiency and its determinants among women undergoing in vitro fertilization treatment for infertility in sweden |
| topic | vitamin D insufficiency 25-hydroxyvitamin D infertility in vitro fertilization dietary assessment sun exposure |
| url | https://www.mdpi.com/2072-6643/15/12/2820 |
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