MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria
ABSTRACTThe Corpus callosum (CC) is the largest commissural fibre tract, ensuring swift information transfer and integration in both cerebral hemispheres. Variations in morphometry exist. There is a paucity of data on CC dimensions in our subregion, and no standardized reference is available. The st...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Libyan Journal of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19932820.2023.2188649 |
| _version_ | 1797450025501982720 |
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| author | Enyereibe Chuks Ajare Francis Chukwuebuka Campbell Emeka K Mgbe Aghogho O. Efekemo Augustine Chukwudi Onuh A. O. Nnamani Okwuoma Okwunodulu Samuel C. Ohaegbulam |
| author_facet | Enyereibe Chuks Ajare Francis Chukwuebuka Campbell Emeka K Mgbe Aghogho O. Efekemo Augustine Chukwudi Onuh A. O. Nnamani Okwuoma Okwunodulu Samuel C. Ohaegbulam |
| author_sort | Enyereibe Chuks Ajare |
| collection | DOAJ |
| description | ABSTRACTThe Corpus callosum (CC) is the largest commissural fibre tract, ensuring swift information transfer and integration in both cerebral hemispheres. Variations in morphometry exist. There is a paucity of data on CC dimensions in our subregion, and no standardized reference is available. The study aims to determine the CC dimensions among the adult population in southeast Nigeria. The result will provide reference ranges and form a benchmark for comparisons of CC-related pathologies. A retrospective study of CC morphometric dimensions in normal subjects who had cranial MRI over two years in Memfys Hospital, Enugu, Southeast Nigeria, using a 1.5T GE© 16 channel machine. The CC was segmentalized into seven subregions using the modified Witelson method with special computer software. All measurements were taken twice from the T1 mid-sagittal image, and the mean was used for computation. The results were analyzed using descriptive and inferential statistics. A total of 200 subjects were recruited for the study. The mean length and height of the CC were 75.58 ± 4.52 mm and 24.64 ± 3.40 mm, respectively. The width dimensions of the genu, body, rostrum and splenium were 10.88 ± 1.81 mm, 5.66 ± 1.32 mm, 3.65 ± 1.25 mm, and 10.02 ± 1.70 mm, respectively. No gender variations were noted among the different dimensions of CC (P = 0.90). The length and height of CC increase gradually with age and show a positive correlation. The width dimensions of the genu and splenium increase till middle age and subsequently decreases in line with brain atrophy (p = 0.0000& p = 0.004). Using Pearson’s correlation test, no correlation was noted in the dimensions of the body and rostrum of the corpus callosum when related to age and sex. (P = 0.92 & p = 0.66). Reference ranges of CC dimensions in our subregion were presented, and variations exist in its different morphometric dimensions which are affected by brain atrophy. Gender does not influence the dimensions in our subpopulations. |
| first_indexed | 2024-03-09T14:34:30Z |
| format | Article |
| id | doaj.art-497669d01cc14637a925d1d2d20f302e |
| institution | Directory Open Access Journal |
| issn | 1993-2820 1819-6357 |
| language | English |
| last_indexed | 2024-03-09T14:34:30Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Libyan Journal of Medicine |
| spelling | doaj.art-497669d01cc14637a925d1d2d20f302e2023-11-27T14:59:05ZengTaylor & Francis GroupLibyan Journal of Medicine1993-28201819-63572023-12-0118110.1080/19932820.2023.2188649MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast NigeriaEnyereibe Chuks Ajare0Francis Chukwuebuka Campbell1Emeka K Mgbe2Aghogho O. Efekemo3Augustine Chukwudi Onuh4A. O. Nnamani5Okwuoma Okwunodulu6Samuel C. Ohaegbulam7Department of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu, NigeriaDepartment of Neurosurgery, Memfys Hospital, Enugu, NigeriaDepartment of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu, NigeriaDepartment of Radiology, University of Benin Teaching Hospital, Benin City, NigeriaDepartment of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu, NigeriaDepartment of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu, NigeriaDepartment of Neurosurgery, Memfys Hospital, Enugu, NigeriaDepartment of Neurosurgery, Memfys Hospital, Enugu, NigeriaABSTRACTThe Corpus callosum (CC) is the largest commissural fibre tract, ensuring swift information transfer and integration in both cerebral hemispheres. Variations in morphometry exist. There is a paucity of data on CC dimensions in our subregion, and no standardized reference is available. The study aims to determine the CC dimensions among the adult population in southeast Nigeria. The result will provide reference ranges and form a benchmark for comparisons of CC-related pathologies. A retrospective study of CC morphometric dimensions in normal subjects who had cranial MRI over two years in Memfys Hospital, Enugu, Southeast Nigeria, using a 1.5T GE© 16 channel machine. The CC was segmentalized into seven subregions using the modified Witelson method with special computer software. All measurements were taken twice from the T1 mid-sagittal image, and the mean was used for computation. The results were analyzed using descriptive and inferential statistics. A total of 200 subjects were recruited for the study. The mean length and height of the CC were 75.58 ± 4.52 mm and 24.64 ± 3.40 mm, respectively. The width dimensions of the genu, body, rostrum and splenium were 10.88 ± 1.81 mm, 5.66 ± 1.32 mm, 3.65 ± 1.25 mm, and 10.02 ± 1.70 mm, respectively. No gender variations were noted among the different dimensions of CC (P = 0.90). The length and height of CC increase gradually with age and show a positive correlation. The width dimensions of the genu and splenium increase till middle age and subsequently decreases in line with brain atrophy (p = 0.0000& p = 0.004). Using Pearson’s correlation test, no correlation was noted in the dimensions of the body and rostrum of the corpus callosum when related to age and sex. (P = 0.92 & p = 0.66). Reference ranges of CC dimensions in our subregion were presented, and variations exist in its different morphometric dimensions which are affected by brain atrophy. Gender does not influence the dimensions in our subpopulations.https://www.tandfonline.com/doi/10.1080/19932820.2023.2188649Corpus callosummorphometric dimensionssubregionreference rangesSoutheast Nigeria |
| spellingShingle | Enyereibe Chuks Ajare Francis Chukwuebuka Campbell Emeka K Mgbe Aghogho O. Efekemo Augustine Chukwudi Onuh A. O. Nnamani Okwuoma Okwunodulu Samuel C. Ohaegbulam MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria Libyan Journal of Medicine Corpus callosum morphometric dimensions subregion reference ranges Southeast Nigeria |
| title | MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria |
| title_full | MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria |
| title_fullStr | MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria |
| title_full_unstemmed | MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria |
| title_short | MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria |
| title_sort | mri based morphometric analysis of corpus callosum dimensions of adults in southeast nigeria |
| topic | Corpus callosum morphometric dimensions subregion reference ranges Southeast Nigeria |
| url | https://www.tandfonline.com/doi/10.1080/19932820.2023.2188649 |
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