The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature
Background: Calcium oxalate kidney stone is one of the common diseases in the urinary system and has a high recurrence rate. Currently, the pathogenesis of kidney stone and the methods to prevent recurrence are still being investigated. Autophagy, as an event of cellular self-repair, has received at...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1008264/full |
| _version_ | 1811271897319473152 |
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| author | Hao Li Hao Li Yingjian Zhou Yingjian Zhou Wenchao Xu Wenchao Xu Jihong Liu Jihong Liu Shaogang Wang Shaogang Wang Hongyang Jiang Hongyang Jiang |
| author_facet | Hao Li Hao Li Yingjian Zhou Yingjian Zhou Wenchao Xu Wenchao Xu Jihong Liu Jihong Liu Shaogang Wang Shaogang Wang Hongyang Jiang Hongyang Jiang |
| author_sort | Hao Li |
| collection | DOAJ |
| description | Background: Calcium oxalate kidney stone is one of the common diseases in the urinary system and has a high recurrence rate. Currently, the pathogenesis of kidney stone and the methods to prevent recurrence are still being investigated. Autophagy, as an event of cellular self-repair, has received attention in the field of kidney stone in recent years. In some current studies, autophagy has shown destructiveness and protectiveness in the pathogenesis of kidney stone. The inhibition or promotion of autophagy may be a key target for future kidney stone therapy. This systematic literature review discusses the function of autophagy in kidney stone pathogenesis in the context of current research and synthesizes the evidence analysis to provide a basis for new future therapies.Method: We systematically reviewed the literature during September 2021 according to the Preferred Reporting Items for Systematic Evaluation and Meta-Analysis (PRISMA) guidelines. Articles on studying the role of autophagy in the pathogenesis of calcium oxalate kidney stone were extracted from PubMed, MEDLINE, Embase and Scopus, including in vivo versus in vitro experiments. The study topic, language and publication date were not restricted. Two authors (Li and Zhou) searched and screened the literature.Results: We screened 18 articles from the 33 collected articles, of which 6 conducted in vitro cellular studies, four conducted animal studies, eight conducted cellular studies with animal studies, and five studied human specimens. In early studies, the literature generally concluded that autophagy is deleterious in the development of kidney stone. In 2020, the idea of the protectiveness of autophagy associated with kidney stone was first proposed and focused on targeting transcription factor EB. In addition, the interaction of autophagy with other cellular events and the regulation of signaling molecules are focused on in this paper.Conclusion: This systematic review provides advances in research on the role of autophagy in renal calculi. The current studies suggest that both upregulation and downregulation of autophagy may ameliorate injury in kidney stone models. The authors prefer the upregulation of autophagy as a future research direction for kidney stone treatment. |
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| format | Article |
| id | doaj.art-49776100133344eba84d0d20cd3e8b9c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T22:30:27Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-49776100133344eba84d0d20cd3e8b9c2022-12-22T03:13:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-09-011310.3389/fphys.2022.10082641008264The role of autophagy in calcium oxalate kidney stone: A systematic review of the literatureHao Li0Hao Li1Yingjian Zhou2Yingjian Zhou3Wenchao Xu4Wenchao Xu5Jihong Liu6Jihong Liu7Shaogang Wang8Shaogang Wang9Hongyang Jiang10Hongyang Jiang11Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBackground: Calcium oxalate kidney stone is one of the common diseases in the urinary system and has a high recurrence rate. Currently, the pathogenesis of kidney stone and the methods to prevent recurrence are still being investigated. Autophagy, as an event of cellular self-repair, has received attention in the field of kidney stone in recent years. In some current studies, autophagy has shown destructiveness and protectiveness in the pathogenesis of kidney stone. The inhibition or promotion of autophagy may be a key target for future kidney stone therapy. This systematic literature review discusses the function of autophagy in kidney stone pathogenesis in the context of current research and synthesizes the evidence analysis to provide a basis for new future therapies.Method: We systematically reviewed the literature during September 2021 according to the Preferred Reporting Items for Systematic Evaluation and Meta-Analysis (PRISMA) guidelines. Articles on studying the role of autophagy in the pathogenesis of calcium oxalate kidney stone were extracted from PubMed, MEDLINE, Embase and Scopus, including in vivo versus in vitro experiments. The study topic, language and publication date were not restricted. Two authors (Li and Zhou) searched and screened the literature.Results: We screened 18 articles from the 33 collected articles, of which 6 conducted in vitro cellular studies, four conducted animal studies, eight conducted cellular studies with animal studies, and five studied human specimens. In early studies, the literature generally concluded that autophagy is deleterious in the development of kidney stone. In 2020, the idea of the protectiveness of autophagy associated with kidney stone was first proposed and focused on targeting transcription factor EB. In addition, the interaction of autophagy with other cellular events and the regulation of signaling molecules are focused on in this paper.Conclusion: This systematic review provides advances in research on the role of autophagy in renal calculi. The current studies suggest that both upregulation and downregulation of autophagy may ameliorate injury in kidney stone models. The authors prefer the upregulation of autophagy as a future research direction for kidney stone treatment.https://www.frontiersin.org/articles/10.3389/fphys.2022.1008264/fullautophagycalcium oxalate stonekidney stonenephrolithaisiscalcium oxalate |
| spellingShingle | Hao Li Hao Li Yingjian Zhou Yingjian Zhou Wenchao Xu Wenchao Xu Jihong Liu Jihong Liu Shaogang Wang Shaogang Wang Hongyang Jiang Hongyang Jiang The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature Frontiers in Physiology autophagy calcium oxalate stone kidney stone nephrolithaisis calcium oxalate |
| title | The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature |
| title_full | The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature |
| title_fullStr | The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature |
| title_full_unstemmed | The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature |
| title_short | The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature |
| title_sort | role of autophagy in calcium oxalate kidney stone a systematic review of the literature |
| topic | autophagy calcium oxalate stone kidney stone nephrolithaisis calcium oxalate |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1008264/full |
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