Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
An E. coli and K. pneumoniae phenotype resistant to piperacillin/tazobactam has recently emerged. Here, the authors show that hyperproduction of the β-lactamase driving this resistance occurs due to excision and reinsertion of a translocatable unit containing bla TEM-1B, creating a tandem array.
Bibliographic Details
| Main Authors: |
Alasdair T. M. Hubbard,
Jenifer Mason,
Paul Roberts,
Christopher M. Parry,
Caroline Corless,
Jon van Aartsen,
Alex Howard,
Issra Bulgasim,
Alice J. Fraser,
Emily R. Adams,
Adam P. Roberts,
Thomas Edwards |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2020-10-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-020-18668-2
|
|---|