Advanced Glycation End Products Upregulate CD40 in Human Retinal Endothelial and Müller Cells: Relevance to Diabetic Retinopathy

Advanced Glycation End Products Upregulate CD40 in Human Retinal Endothelial and Müller Cells: Relevance to Diabetic Retinopathy

CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated in these cells in patients with DR. CD40 upregulation is a central feature of CD40-driven inflammatory disorders. What drives CD40 upregulatio...

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Bibliographic Details
Main Authors: Jose-Andres C. Portillo, Amelia Pfaff, Sarah Vos, Matthew Weng, Ram H. Nagaraj, Carlos S. Subauste
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
retina
diabetes
inflammation
adhesion molecule
chemokine
fibronectin
Online Access:https://www.mdpi.com/2073-4409/13/5/429

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