Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma
OBJECTIVES: To determine the sensitivity of Immunohistochemistry for confirmation of diagnosis of prostate adenocarcinoma in our setup. METHODOLOGY: This descriptive cross sectional study was conducted at Pathology Department of Shaukat Khanum Memorial Cancer Hospital and Research Center, in a peri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Liaquat University of Medical and Health Sciences
2020-12-01
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| Series: | JLUMHS |
| Subjects: | |
| Online Access: | https://www.lumhs.edu.pk/jlumhs/Vol19No04/12.pdf |
| Summary: | OBJECTIVES: To determine the sensitivity of Immunohistochemistry for confirmation of diagnosis of prostate adenocarcinoma in our setup.
METHODOLOGY: This descriptive cross sectional study was conducted at Pathology Department of Shaukat Khanum Memorial Cancer Hospital and Research Center, in a period of six months from September 2012 to March 2013, taking a sample size of 80 biopsy proven cases of prostatic Adenocarcinoma with Non-probability purposive sampling technique. SPSS version 16 was used for data analysis. The qualitative variables like expression of AMACR were presented as frequencies and percentages. Chi square was used with a p value <0.05 taken as significant.
RESULTS: The mean ± SD age of patients was 67.81±7.25 years with a range from 51 to 85 years. The mean ± SD Gleason score of these patients was 6.99±1.52. About 51.2% (n=41) patients were of age group 61-70 years, 33.8% (n=27) were between 71-80 years, only 2.5% (n=2) were of age 81 years and above. Well-differentiated cases of prostatic adenocarcinoma were 3.8% (n=3), 52.5% (n=42) were moderately while 43.8% (n=35) were poorly differentiated. Out of all 100% (n=80) cases 91.2% (n=73) were expressed positive with AMACR staining while remaining 8.8% (n=7) were AMACR negative.
CONCLUSION: AMACR staining is highly sensitive diagnostic tool and should be carried out in all patients who present with doubtful picture of prostatic cancer. |
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| ISSN: | 1729-0341 2309-8627 |